Proposed changes in the classification of carcinogenic chemicals in the work area

Regulatory Toxicology and Pharmacology : RTP
H G NeumannH E Wichmann

Abstract

Carcinogenic chemicals in the work area are currently classified into three categories in Section III of the German List of MAK and BAT Values. This classification is based on qualitative criteria and reflects essentially the weight of evidence available for judging the carcinogenic potential of the chemicals. It is proposed that these Categories--IIIA1, IIIA2, and IIIB--be retained as Categories 1, 2, and 3, to conform with EU regulations. On the basis of our advancing knowledge of reaction mechanisms and the potency of carcinogens, it is now proposed that these three categories be supplemented with two additional categories. The essential feature of substances classified in the new categories is that exposure to these chemicals does not convey a significant risk of cancer to man, provided that an appropriate exposure limit (MAK value) is observed. It is proposed that chemicals known to act typically by nongenotoxic mechanisms and for which information is available that allows evaluation of the effects of low-dose exposures be classified in Category 4. Genotoxic chemicals for which low carcinogenic potency can be expected on the basis of dose-response relationships and toxicokinetics and for which risk at low doses can be asse...Continue Reading

References

Aug 1, 1994·Mutation Research·A F McFeeM D Shelby
Jan 1, 1993·Archives of Toxicology·J G FilserW Kessler

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Citations

Dec 23, 1998·Environmental Health Perspectives·R BartschH Greim
Aug 4, 2004·Mutation Research·Helmut A Greim
Aug 27, 2005·Toxicology Letters·Thomas SchuppJan G Hengstler
Aug 28, 2004·International Journal of Hygiene and Environmental Health·Joachim BruchBice Fubini
Dec 10, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Heinz-Peter GelbkeSophie Duhayon
Apr 4, 2017·Regulatory Toxicology and Pharmacology : RTP·Michael L DoursonJohn Reichard

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