Proposed criteria for interpretation of susceptibilities of strains of Neisseria gonorrhoeae to ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, and norfloxacin.

Antimicrobial Agents and Chemotherapy
J S KnappW L Whittington

Abstract

The susceptibilities of 45 strains of Neisseria gonorrhoeae, including 25 strains susceptible to ciprofloxacin (MICs, < or = 0.06 microgram/ml) and 20 strains exhibiting decreased susceptibilities to ciprofloxacin (MICs, > or = 0.125 microgram/ml), to ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, norfloxacin, and nalidixic acid were determined by agar dilution and disk diffusion. On the basis of theoretical calculations of predicted susceptibilities at which infections may fail therapy (supported by observed failures of infections to respond to the therapeutic doses of enoxacin and ciprofloxacin), the Centers for Disease Control and Prevention has adopted the following agar dilution breakpoints for interpretation of resistance to these agents: MICs of > or = 1.0 microgram of ciprofloxacin, enoxacin, and norfloxacin per ml and MICs of > or = 2.0 micrograms of ofloxacin and lomefloxacin per ml. The corresponding disk diffusion breakpoints for these agents were as follows: ciprofloxacin, < or = 29 mm; ofloxacin, < or = 24 mm; enoxacin, < or = 31 mm; lomefloxacin, < or = 26 mm; and norfloxacin, < or = 32 mm. The Centers for Disease Control and Prevention recommends two strains as interim quality control strains for susceptibili...Continue Reading

References

Apr 1, 1979·Antimicrobial Agents and Chemotherapy·H W JaffeJ D Thayer
Aug 1, 1992·Antimicrobial Agents and Chemotherapy·T E ClendennenF S Wignall
Jan 20, 1992·The Medical Journal of Australia·J W TapsallR Munro
Feb 1, 1991·Journal of Clinical Pathology·A TurnerK R Gough
Jan 20, 1990·Lancet·A E Jephcott, A Turner
Aug 1, 1994·Genitourinary Medicine·H BirleyJ Fletcher

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Citations

Apr 5, 2001·Current Infectious Disease Reports·Janine R. Tompkins, Jonathan M. Zenilman
Oct 19, 2002·International Journal of Antimicrobial Agents·Prashini MoodleyA Willem Sturm
Jun 9, 2006·The New England Journal of Medicine·Debasish SahaMichael L Bennish
Jun 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A CrumpFrederick J Angulo
Apr 8, 2006·Sexually Transmitted Diseases·Elizabeth A DoneganJoan S Knapp
Apr 17, 2012·Sexually Transmitted Diseases·Philippe R S Lagace-WiensSupriya D Mehta
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·M LesmanaB A Oyofo
Aug 15, 2001·Antimicrobial Agents and Chemotherapy·A MavroidiE Tzelepi
Feb 3, 2007·Journal of Clinical Microbiology·Mark J SiednerJeffrey D Klausner
Jul 22, 1998·International Journal of STD & AIDS·J R SchwebkeS H Vermund
Jan 1, 1997·Emerging Infectious Diseases·J S KnappW L Whittington
Dec 12, 2013·Journal of Materials Science. Materials in Medicine·Vinay K SinghKrishna Pramanik
Apr 17, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M R Aplasca De Los ReyesK K Holmes
Jun 21, 2005·Infectious Disease Clinics of North America·Khalil G GhanemJonathan M Zenilman
Mar 20, 2001·Lancet·C IsonL Greene
Apr 23, 2004·Expert Opinion on Pharmacotherapy·Michael Dan

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