Proposed cut-off for reactivity of anti-HMGCR and anti-SRP antibodies in patients statin-exposed and statin-unexposed

Medicine
Alzira Alves Siqueira CarvalhoFernando Luiz Affonso Fonseca

Abstract

The therapeutic approach with statins is widely used in the control of dyslipidemias. However, there is no laboratory evaluation to elect patients to make use of this class of therapeutic drugs.We analyzed the prevalence of anti-signal recognition particle (anti-SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies in a heterogeneous cohort of 85 patients in order to determine cutoff reference values for these antibodies.Serum samples from 85 patients were screened for the presence of anti-HMGCR and anti-SRP autoantibodies by enzyme-linked immunosorbent assay. The demographic, clinical, and morphological features were also correlated with anti-HMGCR and anti-SRP antibodies. The patients were divided in 2 groups: A, statin-exposed, and B, statin-unexposed.There was no significant association (P > .05) among anti-HMGCR and anti-SRP titers in relation to age, sex, statin exposure, and CK level. The concentrations of both antibodies were not correlated with symptoms, CK level, or statin exposure. Eleven (12.9%) patients had anti-HMGCR antibodies. We found a tendency (P = .051) toward greater anti-HMGCR positivity in women with no symptoms. Twelve (14.1%) patients had anti-SRP antibodies. There was no...Continue Reading

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W H ReevesG Blobel
May 9, 2006·Annals of the Rheumatic Diseases·G J D HengstmanB G M van Engelen
Oct 9, 2009·Muscle & Nerve·Phyllis Grable-EspositoAnthony A Amato
Jun 10, 2011·Nature Reviews. Neurology·Andrew L Mammen
Apr 18, 2014·Journal of Immunology Research·Lucile MussetMichael Mahler
Oct 23, 2015·Expert Review of Clinical Immunology·Albert Selva-O'CallaghanIago Pinal-Fernandez

❮ Previous
Next ❯

Citations

Oct 10, 2020·BMJ Case Reports·Izadora Fonseca Zaiden SoaresAlzira Alves de Siqueira Carvalho
Mar 5, 2021·Curēus·Sri Harsha BoppanaNageshwara Gullapalli

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
biopsy

Software Mentioned

Data Analysis and Statistical Software for Professionals ( Sta...

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.