Abstract
Retapamulin, the first pleuromutilin antimicrobial agent approved for the topical treatment of skin infections in humans, was tested against 987 clinical isolates representing 30 species and/or resistance groups. MICs were determined along with disk diffusion zone diameters using a 2-microg disk. Population distribution and MIC versus disk zone diameter scattergrams were analyzed to determine microbiological MIC cutoff values and inhibition zone correlates. Minimum bactericidal concentrations were performed on a smaller subset of key species. The retapamulin MIC(90) against 234 Staphylococcus aureus isolates and 110 coagulase-negative staphylococci was 0.12 microg/ml. Retapamulin MIC(90)s ranged from 0.03 to 0.06 microg/ml against beta-hemolytic streptococci including 102 Streptococcus pyogenes, 103 Streptococcus agalactiae, 59 group C Streptococcus, and 71 group G Streptococcus isolates. The MIC(90) against 55 viridans group streptococci was 0.25 microg/ml. Retapamulin had very little activity against 151 gram-negative bacilli and most of the Enterococcus species tested. Based on the data from this study, for staphylococci, MICs of <or=0.5, 1, and >or=2 microg/ml with corresponding disk diffusion values of >or=20 mm, 17 to 19 ...Continue Reading
References
Mar 1, 1988·Antimicrobial Agents and Chemotherapy·W J Brown
Dec 1, 1970·The Keio Journal of Medicine·K Yamada
Dec 8, 2005·Journal of Clinical Microbiology·James E Ross, Ronald N Jones
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Ellie J C GoldsteinHelen T Fernandez
Jan 27, 2006·Antimicrobial Agents and Chemotherapy·Klaudia Kosowska-ShickPeter C Appelbaum
Sep 1, 1951·Proceedings of the National Academy of Sciences of the United States of America·F KavanaghW J Robbins
Apr 28, 2006·Antimicrobial Agents and Chemotherapy·Glenn A PankuchPeter C Appelbaum
Jun 28, 2006·Antimicrobial Agents and Chemotherapy·Katherine S LongBirte Vester
Jun 28, 2006·Antimicrobial Agents and Chemotherapy·Ronald N JonesJames E Ross
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Kang YanRichard R Gontarek
Oct 27, 2006·Antimicrobial Agents and Chemotherapy·Stephen RittenhouseDavid Payne
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Chen DavidovichAda Yonath
Apr 4, 2007·Antimicrobial Agents and Chemotherapy·Daniel R GentryDavid J Holmes
Jun 9, 2007·Molecular Microbiology·Seok-Ming TohAlexander S Mankin
Jul 17, 2007·Clinical Microbiology Reviews·John Turnidge, David L Paterson
Apr 9, 2008·Antimicrobial Agents and Chemotherapy·Rodrigo E MendesRonald N Jones
Citations
Sep 16, 2010·The Journal of Antimicrobial Chemotherapy·Rodrigo E MendesRonald N Jones
Feb 4, 2012·Pediatric Dermatology·Scott BangertAdelaide A Hebert
Apr 11, 2013·Antimicrobial Agents and Chemotherapy·Rodrigo E MendesJohn P Quinn
Dec 15, 2010·Antimicrobial Agents and Chemotherapy·David J FarrellWilliam G Love
Feb 24, 2011·Antimicrobial Agents and Chemotherapy·Emilio Pérez-TralleroVictor Iriarte
Feb 23, 2012·Antimicrobial Agents and Chemotherapy·Louisa D'LimaDmitri Debabov
Jun 4, 2010·Journal of Clinical Microbiology·Rodrigo E MendesRayo Morfin-Otero
Apr 7, 2009·Expert Review of Anti-infective Therapy·Nicole E Scangarella-OmanDaryl Hoban
Oct 30, 2015·Annals of Dermatology·Sang Hyun ParkKun Park
Aug 23, 2011·Diagnostic Microbiology and Infectious Disease·Rodrigo E MendesRonald N Jones
May 20, 2014·Clinical Therapeutics·Douglas J BiedenbachMeredith Hackel
Mar 13, 2014·Antimicrobial Agents and Chemotherapy·J Chase McNeilEdward O Mason
Jun 26, 2013·Antimicrobial Agents and Chemotherapy·Louis D SaravolatzLeonard B Johnson
Jun 9, 2017·Clinical Microbiology Reviews·Deborah A WilliamsonBenjamin P Howden
Mar 24, 2017·The Journal of Antimicrobial Chemotherapy·Paulina A HawkinsLesley McGee
Apr 30, 2020·The Journal of Antibiotics·Byoungduck Park, Yu-Hong Min
Nov 5, 2019·Frontiers in Microbiology·Arianna LovatoAnnalisa Polverari
Jul 1, 2020·BMC Microbiology·Wenjing ChenQingzhong Liu
Apr 4, 2021·Antibiotics·Carolina FerreiraIsabel Couto
Mar 4, 2021·The Pediatric Infectious Disease Journal·Ami B PatelBo Shopsin