Proposed regulation of gene expression by glucose in rodent heart.

Gene Regulation and Systems Biology
Martin E YoungH Taegtmeyer

Abstract

During pressure overload-induced hypertrophy, unloading-induced atrophy, and diabetes mellitus, the heart induces 'fetal' genes (e.g. myosin heavy chain beta; mhc beta). We propose that altered glucose homeostasis within the cardiomyocyte acts as a central mechanism for the regulation of gene expression in response to environmental stresses. The evidence is as follows. Forced glucose uptake both ex vivo and in vivo results in mhc isoform switching. Restricting dietary glucose prevents mhc isoform switching in hearts of both GLUT1-Tg mice and rats subjected to pressure overload-induced hypertrophy. Thus, glucose availability correlates with mhc isoform switching under all conditions investigated. A potential mechanism by which glucose affects gene expression is through O-linked glycosylation of specific transcription factors. Glutamine:fructose-6-phosphate amidotransferase (GFAT) catalyzes the flux generating step in UDP-N-acetylglucosamine biosynthesis, the rate determining metabolite in protein glycosylation. Ascending aortic constriction increased intracellular levels of UDP-N-acetylglucosamine, and the expression of gfat2, but not gfat1, in the rat heart. Collectively, the results strongly suggest glucose-regulated gene expr...Continue Reading

References

Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S IzumoV Mahdavi
Aug 1, 1981·Circulation Research·J J MercadierK Schwartz
Mar 15, 1980·The Biochemical Journal·H TaegtmeyerH A Krebs
Jan 1, 1993·Annual Review of Physiology·I Komuro, Y Yazaki
Oct 1, 1996·Genome Research·U E GibsonP M Williams
Apr 29, 1998·Metabolism: Clinical and Experimental·H Yki-JärvinenW K Gottschalk
Oct 29, 1998·The Journal of Biological Chemistry·G W GoodwinH Taegtmeyer
Nov 24, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·P H Sugden, A Clerk
Dec 22, 1999·The Proceedings of the Nutrition Society·P Ferré
Jul 11, 2000·Journal of Molecular and Cellular Cardiology·C DepreH Taegtmeyer
Aug 10, 2000·The Journal of Biological Chemistry·S VaulontA Kahn
Feb 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·G W GoodwinH Taegtmeyer
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M E YoungH Taegtmeyer
Apr 3, 2001·Trends in Cardiovascular Medicine·P M Barger, D P Kelly
Sep 11, 2001·Biochemical and Biophysical Research Communications·P RazeghiH Taegtmeyer
Sep 14, 2001·Metabolism: Clinical and Experimental·T DoenstH Taegtmeyer
Mar 1, 1955·The American Journal of Medicine·I UNGARR J BING
Dec 26, 2006·Nature·Nico MitroEnrique Saez

❮ Previous
Next ❯

Citations

Jan 28, 2014·Current Cardiovascular Risk Reports·Ijeoma Ananaba EkeruoHeinrich Taegtmeyer
Jul 11, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Moritz SchnelleAjay M Shah
Jun 18, 2009·American Journal of Physiology. Endocrinology and Metabolism·Louis Hue, Heinrich Taegtmeyer
Apr 20, 2011·Cardiovascular Research·Stephen C Kolwicz, Rong Tian
Nov 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Boglarka LaczyJohn C Chatham
Nov 14, 2018·Frontiers in Endocrinology·Simon DucheixXavier Prieur

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
PCR
PCA
glycosylation
environmental stresses

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.