Proposed systematic nomenclature for orbitides

Journal of Natural Products
Youn Young ShimMartin J T Reaney

Abstract

Orbitides are short (5-11 amino acid residue), ribosomally synthesized homodetic plant cyclic peptides characterized by N-to-C amide bonds rather than disulfide bonds. Orbitides can be discovered using mass spectrometry of plant extracts or by identifying DNA sequences coding for the precursor protein. The number of orbitides that have been characterized to date, by a number of different research groups, is modest. The nomenclatural system currently used for the Type VI cyclic peptides has been developed in an ad hoc fashion and is somewhat arbitrary. We propose a systematic naming system specifically for the Type VI cyclic peptides that reflects the taxonomic name of the species producing the orbitides and a numbering system that enables systematic representation of amino acid residues and modifications. The proposed naming system emulates the IUPAC Nomenclature for Natural Products and UniProt, both of which use abbreviations of taxonomic names for the compounds in question. Nomenclature for post-translational modifications also follows the IUPAC precedent, as well as the cyclic peptide literature. Furthermore, the proposed system aims to maintain agreement with the precedents set by the pre-existing literature. An example of...Continue Reading

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Citations

Nov 13, 2015·Journal of Natural Products·Priscila de M Cândido-BacaniWalmir S Garcez
Apr 16, 2016·Journal of Natural Products·Pâmela J Dos S BeirigoVirgínia C da Silva
Mar 18, 2015·Journal of Natural Products·Peta-Gaye G BurnettMartin J T Reaney
Jun 4, 2016·Journal of Agricultural and Food Chemistry·Peta-Gaye Gillian BurnettMartin John Tarsisius Reaney
Nov 11, 2018·The Biochemical Journal·Marcelo Lattarulo CamposOctávio Luiz Franco
May 23, 2018·BMC Plant Biology·Peta-Gaye Gillian BurnettMartin John Tarsisius Reaney
Oct 6, 2015·Chemistry : a European Journal·Pramodkumar D JadhavMartin J T Reaney
Apr 17, 2020·Frontiers in Genetics·Dmitrii Y TravinKonstantin Severinov
Jul 4, 2020·Journal of Industrial Microbiology & Biotechnology·Garret M Rubin, Yousong Ding
Apr 14, 2020·International Journal of Food Sciences and Nutrition·Xian-Guo ZouZe-Yuan Deng
May 1, 2021·International Journal of Molecular Sciences·Jia-Nan ZhangHong-Jie Zhang
Sep 12, 2017·Accounts of Chemical Research·Wenjia Gu, Eric W Schmidt
Oct 21, 2016·Bioconjugate Chemistry·Pramodkumar D JadhavMartin J T Reaney
Nov 6, 2018·Journal of the American Chemical Society·Wenjia GuEric W Schmidt
Jun 3, 2020·Journal of Natural Products·Christopher BérubéNormand Voyer
Apr 3, 2020·Journal of Natural Products·Mark F FisherJoshua S Mylne

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