Proposing low-similarity peptide vaccines against Mycobacterium tuberculosis.

Journal of Biomedicine & Biotechnology
Guglielmo LuccheseDarja Kanduc

Abstract

Using the currently available proteome databases and based on the concept that a rare sequence is a potential epitope, epitopic sequences derived from Mycobacterium tuberculosis were examined for similarity score to the proteins of the host in which the epitopes were defined. We found that: (i) most of the bacterial linear determinants had peptide fragment(s) that were rarely found in the host proteins and (ii) the relationship between low similarity and epitope definition appears potentially applicable to T-cell determinants. The data confirmed the hypothesis that low-sequence similarity shapes or determines the epitope definition at the molecular level and provides a potential tool for designing new approaches to prevent, diagnose, and treat tuberculosis and other infectious diseases.

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Citations

Feb 5, 2013·Schizophrenia Bulletin·Guglielmo LuccheseDarja Kanduc
Dec 18, 2013·Immunotherapy·Jean Pierre Spinosa, Darja Kanduc
Jul 2, 2014·Epilepsy Research and Treatment·Guglielmo LuccheseDarja Kanduc
Jun 15, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Darja Kanduc
May 21, 2013·Journal of Basic Microbiology·Darja KanducGiovanni Capone
Nov 3, 2012·Immunopharmacology and Immunotoxicology·Giovanni CaponeDarja Kanduc
Mar 21, 2012·Immunopharmacology and Immunotoxicology·G Lucchese, A Pesce Delfino
May 19, 2012·Immunopharmacology and Immunotoxicology·Guglielmo Lucchese
Feb 7, 2012·Immunopharmacology and Immunotoxicology·Giovanni CaponeDarja Kanduc
Apr 10, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jagadish Chandrabose SundaramurthiLuke Elizabeth Hanna
Nov 17, 2015·Journal of Immunology Research·Darja KanducLorenzo Polimeno
May 26, 2018·Current Drug Discovery Technologies·Darja Kanduc

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