PMID: 7032183Oct 1, 1981Paper

Propranolol and femoxetine, a HT-uptake inhibitor, in migraine prophylaxis. A double-blind crossover study

Acta Neurologica Scandinavica
P G Andersson, E N Petersen

Abstract

The prophylactic effect of the 5-HT uptake inhibitor femoxetine was compared with propranolol (Frekven R) in a double-blind crossover trial of 6 months duration. Forty-nine patients commenced the trial. Twelve patients withdrew because of drug failure or failure to attend checkups (6), side effects (4) or other non-drug related causes (2). In the 37 patients who completed the trial there was no significant difference between propranolol 160 mg and femoxetine 400 mg with respect to the number of headache days or the number of migraine attacks during the last 2 months of each treatment, Propranolol, however, was superior to femoxetine when the headache index was used (P less than 0.05). The study has shown that partial depletion of thrombocyte 5-HT by a 5-HT uptake inhibitor does not lead to a marked improvement in all patients contrary to what might be expected from the 5-HT hypothesis of migraine. Nevertheless, due to the infrequent subjective side effects associated with femoxetine treatment it may be a valuable prophylactic drug to a subgroup of migraine patients.

Citations

Mar 1, 1983·Acta Neurologica Scandinavica·A BaldratiT Sacquegna
May 15, 1995·Statistics in Medicine·B Jones, J A Lewis
Feb 18, 2017·The Cochrane Database of Systematic Reviews·Klaus Linde, Karin Rossnagel
Oct 1, 1983·Acta Neurologica Scandinavica·P J KangasniemiE Petersen
Sep 17, 2002·Cephalalgia : an International Journal of Headache·S D Silberstein, P J Goadsby
Jan 1, 1988·Cephalalgia : an International Journal of Headache·C H LückingD Soyka

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