PMID: 1688102Jan 1, 1991Paper

Propranolol and thyroid hormone metabolism

Thyroid : Official Journal of the American Thyroid Association
W M Wiersinga

Abstract

Propranolol decreases plasma T3 and increases plasma rT3 in a dose-dependent manner due to a decreased production rate of T3 and a decreased metabolic clearance rate of rT3, respectively, caused by inhibition of the conversion of T4 into T3 and of rT3 into 3,3'-T2. This inhibition of 5'-deiodination is not secondary to inhibition of thyroid hormone transport across the plasma membrane. Propranolol and its major metabolite, 4-hydroxypropranolol, are not directly responsible for these effects, but an unidentified metabolite of propranolol might be involved. beta-blockers ameliorate clinical symptoms and signs of thyrotoxicosis independent of the decrease of plasma 13, that is confined to beta-blockers with membrane-stabilizing activity, such as propranolol and alprenolol. The decrease of plasma T3, however, appears responsible for some of the metabolic responses to beta-blockers.

References

Sep 1, 1976·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·U B LauridsenJ Nerup
Mar 1, 1978·The Journal of Clinical Endocrinology and Metabolism·C W ZwillichJ V Weil
Sep 1, 1978·British Journal of Clinical Pharmacology·D G McDevitt, J K Nelson
Dec 1, 1979·British Journal of Clinical Pharmacology·L E MurchisonP D Bewsher
Jan 1, 1979·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J FaberP Theilade
Apr 16, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·I Andersen
May 1, 1979·Clinical Endocrinology·J FeelyJ Crooks
May 1, 1979·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C J van NoordenJ L Touber
Dec 1, 1979·The Journal of Clinical Investigation·A S JenningsR D Utiger
May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R P VerhoevenM A Schalekamp
Jul 1, 1978·Clinical Endocrinology·J SaundersP H Sönksen
Feb 1, 1978·Endocrinology·P ChiraseveenuprapundI N Rosenberg
Oct 1, 1975·British Journal of Clinical Pharmacology·J K Nelson, D G McDevitt
Aug 1, 1977·The Journal of Clinical Endocrinology and Metabolism·W M Wiersinga, J L Touber
Dec 1, 1977·Clinical Pharmacology and Therapeutics·B O Kristensen, J Weeke
Apr 1, 1990·Journal of Endocrinological Investigation·L KayserJ E Hansen
Mar 1, 1990·Clinical Endocrinology·O EberP Költringer
May 1, 1985·Postgraduate Medical Journal·M R WilkinsM J Kendall
Feb 1, 1985·Clinical Pharmacology and Therapeutics·R A ReevesF H Leenen
Jan 27, 1973·Lancet·M G Gibberd, J S Staffurth
Jul 1, 1969·Acta Endocrinologica·D R HaddenJ A Weaver
Apr 1, 1981·Postgraduate Medical Journal·M K JonesM Lewis
Jun 1, 1982·British Journal of Clinical Pharmacology·N R PedenJ Crooks
Dec 1, 1982·The American Journal of Medicine·D S CooperE C Ridgway
Sep 1, 1980·Clinical Endocrinology·J HowP D Bewsher
Dec 1, 1981·Clinical Endocrinology·S KaurI Ramsay
Oct 1, 1980·European Journal of Clinical Pharmacology·O R NilssonL Tegler

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Citations

Oct 23, 1998·Molecular and Cellular Endocrinology·M R StulpC Ris-Stalpers
Mar 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lars P KlieverikAndries Kalsbeek
Feb 19, 2008·Thyroid : Official Journal of the American Thyroid Association·J Enrique Silva, Suzy D C Bianco
Sep 5, 2014·Journal of Endocrinological Investigation·Michele MarinòPaolo Vitti
Mar 27, 2012·The Medical Clinics of North America·Joanna Klubo-Gwiezdzinska, Leonard Wartofsky
Apr 6, 2006·Clinical Techniques in Small Animal Practice·Lauren A Trepanier
Jul 22, 2014·The Korean Journal of Internal Medicine·Dong Hun KimSoon-Pyo Hong
Nov 3, 2016·International Journal of Endocrinology·Arnaldo Moura Neto, Denise Engelbrecht Zantut-Wittmann
May 5, 2017·Health Services Insights·Marcia Rashelle Palace
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·M WalkerP Kendall-Taylor
Nov 24, 2018·Environmental Science and Pollution Research International·Shakila SabirAmmara Saleem
Feb 13, 2019·The Journal of Clinical Endocrinology and Metabolism·James E HaddowGlenn E Palomaki
Jun 19, 2001·American Journal of Physiology. Endocrinology and Metabolism·J BurggraafH Pijl
Oct 13, 2020·Annals of Clinical Biochemistry·David J Halsall, Susan Oddy

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