Propranolol can induce PTSD-like memory impairments in rats

Brain and Behavior
Rong-Ting ZhuHu Zhao

Abstract

One hallmark symptom of post-traumatic stress disorder (PTSD) is an inability to restrict fear responses to the appropriate predictor. An infusion of glucocorticoids (GCs) after a high-intensity shock has been shown to induce PTSD-like memory impairments. In addition to GCs, noradrenergic signalling is also recognized as a key biomarker underlying PTSD symptomatology. To explore the role of the noradrenergic system in PTSD-like memory impairments, in this study, various doses of the β-adrenoceptor antagonist propranolol were systemically or bilaterally injected into the dorsal hippocampus immediately after unpaired cue-shock contextual fear conditioning, and then the rats were tested 24 h later. Interestingly, we found that only low-dose propranolol could induce PTSD-like memory impairments, as rats showed reduced freezing to the correct predictor and generalized fear responses to the safe cues, accompanied by increased NE levels in the hippocampus and altered neural activity within the frontal-subcortical circuit. These findings demonstrate that the noradrenergic system is involved in regulating the consolidation of contextual fear memory and that propranolol can dose-dependently induce PTSD-like memory impairments.

References

Jul 1, 1989·Biological Psychiatry·R K Pitman
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·G L QuirarteJ L McGaugh
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Oct 14, 2000·Neurobiology of Learning and Memory·L CahillB Setlow
Mar 13, 2001·Molecular Psychiatry·M Davis, P J Whalen
Aug 2, 2001·The American Journal of Psychiatry·T D GeraciotiJ W Kasckow
Aug 3, 2002·The Journal of Neuropsychiatry and Clinical Neurosciences·Barry Layton, Robert Krikorian
May 20, 2003·The European Journal of Neuroscience·Jin-Zhao JiBao-Ming Li
Nov 6, 2003·Neuroscience and Biobehavioral Reviews·Christian A Heidbreder, Henk J Groenewegen
Apr 7, 2004·Cell·Charles F MurchisonSteven A Thomas
Apr 15, 2004·Neurobiology of Learning and Memory·Elisabetta BaldiCorrado Bucherelli
Sep 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benno RoozendaalJames L McGaugh
Aug 16, 2005·Journal of Chemical Neuroanatomy·Ken W S Ashwell, George Paxinos
Oct 18, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·David A MorilakCorina O Petre
Aug 8, 2006·Annals of the New York Academy of Sciences·Lisa M ShinRoger K Pitman
Mar 6, 2007·European Journal of Applied Physiology·A ViruA C Hackney
Mar 14, 2007·Depression and Anxiety·J R Strawn, T D Geracioti
Jul 7, 2007·Neurobiology of Learning and Memory·Pierre TrifilieffJacques Micheau
Oct 13, 2007·Neurobiology of Learning and Memory·Michael R Hunsaker, Raymond P Kesner
Nov 1, 2007·The International Journal of Neuropsychopharmacology·Elizabeth J VidelockArieh Y Shalev
Nov 1, 2007·The International Journal of Neuropsychopharmacology·Arieh Y ShalevRachel Yehuda
Nov 27, 2007·Progress in Brain Research·Israel Liberzon, Chandra Sekhar Sripada
May 21, 2008·Journal of Abnormal Psychology·Stephen D SmithDavid H Zald
Jun 3, 2008·Current Opinion in Neurobiology·Xin DuanHongjun Song
Sep 2, 2008·Neurobiology of Learning and Memory·Marieke S TollenaarWalter Everaerd
Feb 5, 2009·Nature Reviews. Neuroscience·Susan J Sara
Dec 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Naoe OkamuraRainer K Reinscheid
Mar 8, 2011·Neuropharmacology·Tanja JovanovicMichael Davis
Jun 1, 2011·Neurobiology of Learning and Memory·Marieke Soeter, Merel Kindt
Jun 22, 2011·Neurobiology of Learning and Memory·Carl W Stevenson
Jul 9, 2011·Neuropharmacology·Thomas Steckler, Victoria Risbrough
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Piray AtsakBenno Roozendaal
Mar 1, 2012·Science·Nadia KaouaneAline Desmedt
Oct 11, 2012·Nature Reviews. Neuroscience·Roger K PitmanIsrael Liberzon
Nov 28, 2012·Journal of Psychiatry & Neuroscience : JPN·Michelle H LonerganAlain Brunet
Feb 23, 2013·Behavioural Brain Research·Pierre Lavenex, Pamela Banta Lavenex

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