Propranolol dosage in thyrotoxicosis

The Journal of Clinical Endocrinology and Metabolism
J FeelyJ Crooks

Abstract

Eighteen thyrotoxic patients receiving chronic treatment with propranolol (160 mg/day) were studied to determine the relationship between plasma propranolol concentration and drug effect. There was a considerable interindividual variability in both the plasma propranolol steady state concentration and the degree of beta-adrenergic blockade. The plasma propranolol steady state concentration correlated significantly with both beta-adrenergic blockage and weight change but not with the degree of subjective improvement. In a group of 40 patients, including 10 severely thyrotoxic patients, who had the dosage of propranolol titrated objectively preoperatively to bring about a greater than 25% reduction in exercise heart rate at the end of a dosage interval, no case of thyroid storm was encountered. Many patients, the younger and severely thyrotoxic in particular, require doses in excess of 160 mg/day to achieve this degree of beta-adrenergic blockade.

Citations

Jan 1, 1981·European Journal of Clinical Pharmacology·J FeelyI H Stevenson
Jan 1, 1988·Pharmacology & Therapeutics·J W UpwardC F George
Apr 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Marcia Silva QueirozFaramarz Ismail-Beigi
Mar 26, 1983·British Medical Journal·J FeelyD Maclean
Dec 2, 1995·BMJ : British Medical Journal·V Patel, J J Mukherjee
Apr 1, 1981·Postgraduate Medical Journal·J Feely
Mar 27, 2012·The Medical Clinics of North America·Joanna Klubo-Gwiezdzinska, Leonard Wartofsky
Apr 1, 1984·Anaesthesia·W F HamiltonJ Feely
Jul 1, 1981·British Journal of Clinical Pharmacology·J FeelyI H Stevenson
Dec 1, 1981·British Journal of Clinical Pharmacology·G R JonesD Wynford-Thomas
Aug 1, 1990·AORN Journal·A M Martinelli, J L Fontana
Apr 1, 1982·Scottish Medical Journal·E F Nicol, W J Irvine

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