PMID: 3215847Dec 1, 1988Paper

Propranolol enhances adenine nucleotide degradation in human muscle during exercise

Journal of Applied Physiology
S BrobergK Sahlin

Abstract

Eight healthy men cycled to exhaustion [4.1 +/- 0.3 (SE) min] during beta-adrenoceptor blockade (beta B) with propranolol. The exercise was repeated on another day with the same power output and duration but without propranolol (control). The total adenine nucleotide (TAN) content in muscle (quadriceps femoris) decreased during exercise, and the decrease was more pronounced during beta B (delta TAN = 4.8 +/- 1.0 mmol/kg dry wt) than during control (delta TAN = 2.8 +/- 0.9; P less than 0.01, beta B vs. control). The decrease in TAN corresponded with a similar increase in inosine 5'-monophosphate (IMP). The increase in IMP was more pronounced during beta B (delta IMP = 5.1 +/- 1.2 mmol/kg dry wt) than during control (delta IMP = 2.8 +/- 0.7; P less than 0.05, beta B vs. control). Similarly, the increase in the content of NH3 in muscle was twice as high during beta B vs. control (P less than 0.01). The increase in muscle lactate and the decrease in phosphocreatine during exercise were similar between treatments, but postexercise hexose phosphates were approximately twofold higher (P less than 0.05) during control than during beta B. It is concluded that beta B enhances the degradation of TAN and the production of NH3 and IMP in mu...Continue Reading

Citations

Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·R Mora-RodriguezE F Coyle
Apr 30, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Abram Katz, Håkan Westerblad
Jul 1, 1991·The American Journal of Physiology·M K SpencerA Katz
Jun 1, 1991·The American Journal of Physiology·M K Spencer, A Katz

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