Propranolol for infantile hepatic hemangioendothelioma: Clinical evaluation of drug efficacy and safety using a single-center patient cohort.

Annals of Hepatology
Ruicheng TianSong Gu

Abstract

Infantile hepatic hemangioendothelioma (IHHE) is a benign liver tumor, associated with hypothyroidism and vascular malformations along the skin, brain, digestive tract and other organs. Here, we determined a single-center patient cohort by evaluating the effectiveness and safety of propranolol and sirolimus for the treatment of IHHE. We performed a monocentric and observational study, based on clinical data obtained from 20 cases of IHHE treated with oral propranolol and sirolimus at the Shanghai Children's Medical Center (SCMC), between December 2017 and April 2019. All cases were confirmed by abdominal enhanced CT examination (18/20, 90%) and sustained decrease of alpha fetoprotein (AFP) (2/20, 10%). Propranolol treatment was standardized as once a day at 1.0mg/kg for patients younger than 2 months, and twice a day at 1.0mg/kg (per dose) for patients older than 2 months. Sirolimus was used to treat refractory IHHE patients after 6 months of propranolol treatment, and initial dosing was at 0.8mg/m2 body surface per dose, administered every 12h. Upon treatment, abdominal ultrasound scanning was regularly performed to evaluate any therapeutic effects. All children were followed up for 6-22 months (mean value of 12.75 months). Th...Continue Reading

References

May 15, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Carmen GallegoEnrique García-Hidalgo
Jun 14, 2008·The New England Journal of Medicine·Christine Léauté-LabrèzeAlain Taïeb
Jan 10, 2009·World Journal of Surgery·Suk-Bae MoonSung-Eun Jung
May 22, 2010·The Journal of Pediatrics·Juliette Mazereeuw-HautierChristine Bodemer
May 25, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Eliano Bonaccorsi-Riani, Jan P Lerut
Feb 23, 2011·Cutaneous and Ocular Toxicology·Paulo MoraisFilomena Azevedo
Apr 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·Marco SciveresGiuseppe Maggiore
Sep 29, 2011·Korean journal of pediatrics·Eun Hee KimJong Jin Seo
Nov 1, 2011·Nature Reviews. Drug Discovery·Don BenjaminMichael N Hall
Feb 15, 2012·Journal of Pediatric Gastroenterology and Nutrition·Serine AvagyanRonen Arnon
Jan 20, 2016·Pediatrics·Denise M AdamsRichard G Azizkhan
Jan 6, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giulia VarrassoAnna Clerico
Mar 12, 2017·Cell·Robert A Saxton, David M Sabatini
Mar 21, 2017·La Presse médicale·Ines MaaloulMongia Hachicha
Jun 28, 2017·Drug Discoveries & Therapeutics·Zeynep Canan ÖzdemirÖzcan Bör
Jul 27, 2018·Cardiology in the Young·Kanupriya ChaturvediChristopher S Snyder
Sep 25, 2018·The Journal of Pediatrics·Ionela IacobasSteven J Fishman
Jun 25, 2019·Journal of Pediatric Hematology/oncology·Ahmed EmadAlaa El Haddad

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Citations

Jul 27, 2021·Pediatric Surgery International·Wenli XiuQian Dong

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