Propranolol for treating emotional, behavioural, autonomic dysregulation in children and adolescents with autism spectrum disorders

Journal of Psychopharmacology
Ilyas Sagar-OuriaghliParamala J Santosh

Abstract

To date, there is no single medication prescribed to alleviate all the core symptoms of Autism Spectrum Disorder (ASD; National Institute of Health and Care Excellence, 2016). Both serotonin reuptake inhibitors and drugs for psychosis possess therapeutic drawbacks when managing anxiety and aggression in ASD. This review sought to appraise the use of propranolol as a pharmacological alternative when managing emotional, behavioural and autonomic dysregulation (EBAD) and other symptoms. Sixteen reports examined the administration of propranolol in the context of ASD. Sixteen reports broadly covered cognitive domains, neural correlates, and behavioural domains. From the eight single-dose clinical trials, propranolol led to significant improvements in cognitive performance - verbal problem solving, social skills, mouth fixation, and conversation reciprocity; and changes in neural correlates - improvement in semantic networks and functional connectivity. The remaining eight case series and single case reports showed improvements in EBAD, anxiety, aggressive, self-injurious and hypersexual behaviours. Additionally, propranolol significantly improved similar behavioural domains (aggression and self-injury) for those with acquired brain...Continue Reading

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Citations

Feb 7, 2020·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Sarah M KennedyJill Ehrenreich-May
Dec 5, 2020·Journal of Personalized Medicine·Emily L CasanovaManuel F Casanova
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Jan 16, 2020·American Journal of Therapeutics·Ahmed Naguy, Seshni Moodliar
Nov 12, 2021·Frontiers in Psychiatry·Frank W PaulusChristian Popow

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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT02871349

Software Mentioned

OvidSP

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