Abstract
Propranolol has been recently approved by health authorities to treat infantile haemangiomas (IH). Propranolol is indicated in infants less than 5months of age with an IH requiring systemic therapy: IH at life-threatening and/or functional risk, painful ulcerated IH and IH that may cause permanent disfigurement. Propranolol should be initiated by physicians who have expertise in the diagnosis, treatment and management of IH. In addition, the first intake and every escalation should be administrated in a controlled clinical setting where adequate facilities for handling of adverse reactions, including those requiring urgent measures, are available. Then a monthly monitoring with dose adjustment weight is mandatory by the family doctor. Parents should be informed of the risk of hypoglycaemia and bronchoconstriction, especially during respiratory infectious outbreaks. The recommended duration of treatment is 6months without tapering. Relapses are possible necessitating a second course of 3 to 6months of treatment.
References
Jun 14, 2008·The New England Journal of Medicine·Christine Léauté-LabrèzeAlain Taïeb
Jun 2, 2009·Plastic and Reconstructive Surgery·Michele BigorreHuguette Valette
Aug 27, 2009·Pediatrics·Véronique SansChristine Léauté-Labrèze
May 22, 2010·The Journal of Pediatrics·Juliette Mazereeuw-HautierChristine Bodemer
Mar 1, 2011·Journal of the American Academy of Dermatology·Mélanie Saint-JeanUNKNOWN Groupe de Recherche Clinique en Dermatologie Pédiatrique
May 17, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·C Léauté-LabrèzeK Ezzedine
Nov 5, 2011·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·S Hernandez-MartinJ A Tovar
Jul 6, 2012·The British Journal of Dermatology·E PopeM Weinstein
Sep 22, 2012·Pediatric Dermatology·Denise MetryBeth A Drolet
Dec 26, 2012·Pediatrics·Beth A DroletIlona J Frieden
Mar 12, 2013·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C Léauté-Labrèze
May 8, 2013·Pediatrics·Hsien ChanOrli Wargon
May 15, 2013·The British Journal of Dermatology·C K AhogoC Léauté-Labrèze
Sep 10, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·M de GraafS G M A Pasmans
Feb 19, 2015·The New England Journal of Medicine·Christine Léauté-LabrèzeJean-Jacques Voisard
Citations
Feb 3, 2016·Seminars in Perinatology·Kay D BeharryJacob V Aranda
Jan 4, 2017·The Journal of Dermatological Treatment·Jelena PetrovicVojislav Parezanović
Dec 3, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·F HartmannK-M Thoms
Aug 29, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Franziska HartmannKai-Martin Thoms
Sep 29, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Franziska HartmannKai-Martin Thoms