PMID: 686315Jun 1, 1978Paper

Propranolol in thyrotoxicosis. Cardiovascular changes during thyroidectomy in patients pre-treated with propranolol

A J TrenchD B Scott


The cardiovascular changes during anaesthesia and thyroidectomy have been studied in seven thyrotoxic patients prepared with propranolol. The heart rate and cardiac rhythm remained very stable throughout surgery. A 20% increase in mean arterial pressure occurred during surgical stimulation. A decrease in cardiac output, due to decreased stroke volume, occurred during surgical stimulation. A decrease in cardiac output, due to decreased stroke volume, occurred during surgery, reaching a maximum of 21% during ligation of the thyroid vessels and returning to pre-operative values by the end of surgery. The fall in cardiac output was accompanied by raised central venous pressure and raised total peripheral resistance.


Oct 1, 1975·British Journal of Clinical Pharmacology·I Ramsay
Feb 1, 1978·Anaesthesia·D B ScottG B Drummond
May 25, 1974·Lancet·W MichieP D Bewsher
Nov 1, 1974·Annals of Surgery·P D BewsherW Michie
Mar 19, 1966·Lancet·G Howitt, D J Rowlands
Feb 1, 1974·British Journal of Anaesthesia·C Prys-RobertsT J Patterson
Jun 1, 1973·Annals of Surgery·T C LeeJ J Canary

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Sep 1, 1996·Acta Anaesthesiologica Scandinavica·H Breivik
Jun 1, 1983·Journal of Clinical and Hospital Pharmacy·P Foëx
Jan 1, 1992·Pediatric Annals·W Hung
Apr 1, 1984·Anaesthesia·W F HamiltonJ Feely
Jan 1, 1982·Acta Anaesthesiologica Scandinavica. Supplementum·P FoëxG R Cutfield

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