PMID: 645584Apr 1, 1978

Propranolol rebound--a retrospective study

The American Journal of Cardiology
R A ShiroffA H Hayes

Abstract

To assess the effects of sudden withdrawal of propranolol on inpatients with coronary artery disease, 102 patients admitted for cardiac catheterization were evaluated. Criteria for inclusion in the study were angiographically documented coronary artery disease, propranolol therapy at a mean daily dose of at least 80 mg and abrupt discontinuation of propranolol therapy before catheterization. There were 55 patients (mean age 52.5) who discontinued propranolol therapy (mean daily dose 127 mg) and a control group of 47 patients (mean age 53) who continued to receive propranolol (mean daily dose 143 mg). The criteria for morbidity were death, myocardial infarction or change in pain pattern. In the withdrawal group there were no deaths, one myocardial infarction judged to be related to catheterization and only one instance of a change in pain pattern. Thus, propranolol rebound appears to occur infrequently among hospitalized patients with reduced activity.

References

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Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·A D Struthers, C T Dollery
Jan 1, 1984·European Journal of Clinical Pharmacology·K S Kiyingi, J Shaw
Aug 1, 1986·British Heart Journal·P R Walker
May 15, 1987·The American Journal of Cardiology·W H Frishman
Aug 1, 1982·American Heart Journal·R J WaldenB N Prichard
Jul 1, 1979·British Journal of Anaesthesia·I W CarsonR G Shanks
Jan 1, 1982·British Journal of Clinical Pharmacology·B N Prichard, R J Walden
Aug 1, 1978·Circulation·D G Shand, A J Wood
Sep 1, 1987·Medical Toxicology and Adverse Drug Experience·C F George, D Robertson
Oct 1, 1980·Journal of Clinical Pharmacology·H W Moses, P N Yu
Jan 1, 1982·Acta Anaesthesiologica Scandinavica. Supplementum·J PonténA Hjalmarson

Related Concepts

Coronary Heart Disease
Cardiac Catheterization Procedures
Hospitalization
Myocardial Infarction
Rexigen
Retrospective Studies
Withdrawal Symptoms

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