Nov 9, 2018

Proprioceptive neurons of larval Drosophila melanogaster show direction selective activity requiring the mechanosensory channel TMC.

BioRxiv : the Preprint Server for Biology
Liping HeDan Tracey

Abstract

Drosophila Transmembrane channel-like (Tmc) is a protein that functions in larval proprioception. The closely related TMC1 protein is required for mammalian hearing, and is a pore forming subunit of the hair cell mechanotransduction channel. In hair cells, TMC1 is gated by small deflections of microvilli that produce tension on extracellular tip-links that connect adjacent villi. How Tmc might be gated in larval proprioceptors, which are neurons having a morphology that is completely distinct from hair cells, is unknown. Here, we have used high-speed confocal microscopy to both measure displacements of proprioceptive sensory dendrites during larval movement, and to optically measure neural activity of the moving proprioceptors. Unexpectedly, the pattern of dendrite deformation for distinct neurons was unique and differed depending on the direction of locomotion: ddaE neuron dendrites were strongly curved by forward locomotion while the dendrites of ddaD were more strongly deformed by backward locomotion. Furthermore, GCaMP6f calcium signals recorded in the proprioceptive neurons during locomotion indicated tuning to the direction of movement. ddaE showed strong activation during forward locomotion while ddaD showed responses th...Continue Reading

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Mentioned in this Paper

Dendrite of Motor Neuron
Biochemical Pathway
Calcium [EPC]
Patterns
Microvilli
Extracellular
Sensory Dendrite
Membrane
Calcium
Integral Membrane Proteins

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