Proptosis due to intraorbital space-occupying lesions in children.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Alon ZahaviNitza Goldenberg-Cohen

Abstract

To report the 10-year experience of two tertiary medical centers with children presenting with proptosis due to an intraorbital space-occupying lesion. Patients were identified by file review. Data were collected on demographics, findings on ophthalmologic and imaging evaluations, etiology, treatment, and outcome. Nineteen children (7 male) were included. Eleven patients had optic nerve glioma, including 9 with substantially decreased visual acuity. Treatment consisted of chemotherapy alone or with radiation, resection or anti-VEGF agents, MEK inhibitor, or observation only (n = 1). Visual and cosmetic outcomes were poor in all cases. Outcome for arteriovenous malformations was good following corticosteroid treatment (n = 1), but catheterization led to persistent proptosis and fluctuating visual acuity (n = 1). Compound capillary hemangioma (n = 1) was treated with laser and systemic beta blockers with satisfactory results. Rhabdomyosarcoma had a good prognosis in one patient treated with resection and radiation but was fatal in another even after chemotherapy. Juvenile xanthogranuloma, frontal bone osteoma, and localized hypertrophic neuropathy of the supraorbital nerve (n = 1 each) were treated by resection with good visual a...Continue Reading

References

Mar 1, 1994·Survey of Ophthalmology·J J Dutton
Jul 10, 2003·Pediatric Neurology·Sharon L TowAnthony M Avellino
Apr 28, 2004·Survey of Ophthalmology·Dinesh SelvaJack Rootman
Sep 21, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Zeynel A KarciogluSonia DeFrancesco
Sep 8, 2005·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·J L Gil-SalúJ M Vera-Román
Aug 22, 2008·Orbit·Svetlana A TroninaValentina P Khrinenko
Dec 10, 2008·Archives of Ophthalmology·Sunil WarrierDinesh Selva
Apr 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Iyad SultanAndrea Ferrari
Jan 18, 2011·Pediatric Blood & Cancer·Ben ShoftyAnat Kesler
Mar 1, 2012·Ophthalmic Plastic and Reconstructive Surgery·Robert H HillKenneth V Cahill
May 2, 2012·American Journal of Clinical Oncology·Ali VaranMünevver Büyükpamukçu
Sep 25, 2012·Postgraduate Medical Journal·Anne-Caroline BesseroIndran Davagnanam
Jan 1, 2012·FEBS Open Bio·Yosef LavivNitza Goldenberg-Cohen
May 30, 2013·Ophthalmic Plastic and Reconstructive Surgery·Galin J SpicerTimothy J Sullivan
Aug 21, 2013·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Sarah N Khan, Ali R Sepahdari
Oct 15, 2013·Seminars in Ophthalmology·Hatem Krema
Mar 13, 2014·Ophthalmic Plastic and Reconstructive Surgery·Leslie A WeiMark J Lucarelli
Apr 17, 2014·International Ophthalmology·Akshay Gopinathan NairRashmin A Gandhi
Apr 26, 2014·Ophthalmic Plastic and Reconstructive Surgery·Lora R Dagi GlassMichael Kazim
Jan 9, 2016·AJNR. American Journal of Neuroradiology·D T GinatC D Robson
Jul 31, 2016·Clinical & Experimental Ophthalmology·Edwina EadeJames Smith
Jun 28, 2019·Current Opinion in Ophthalmology·Marybeth K FarazdaghiRobert A Avery

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Roberto Jose DiazUte Bartels
Indian Pediatrics
S P DhirG C Jain
JAMA Otolaryngology-- Head & Neck Surgery
Jana M GhulmiyyahBrian K Reilly
Annals of the Royal College of Surgeons of England
J E Wright
Bulletin of the Ophthalmological Society of Egypt
A Mortada
© 2021 Meta ULC. All rights reserved