Propylene glycol releases calcium from mitochondrial stores in rat cerebrocortical synaptosomes

The International Journal of Neuroscience
Eiki SatohMasakazu Nishimura

Abstract

In Ca2+-free medium, propylene glycol (PG) increases the cytosolic-free Ca2+ concentration ([Ca2+]i) in rat cerebrocortical synaptosomes. In the current studies, the authors investigated the intracellular source of this Ca2+. PG (0.5-5% v/v) dose-dependently increased [Ca2+]i in Ca2+-free medium. The increase in [Ca2+]i was completely inhibited by pretreatment with the mitochondrial uncoupler, carbonylcyanide m-chlorophenylhydrazone (CCCP, 10 microM). The inhibitory effect of CCCP was dependent on the concentration and the pretreatment time. These results suggest that, in Ca2+-free medium, PG increases [Ca2+]i in rat cerebrocortical synaptosomes by releasing Ca2+ from mitochondrial stores.

References

Sep 1, 1978·The Journal of Pediatrics·K Arulanantham, M Genel
Aug 18, 1999·Critical Reviews in Toxicology·J S LaKindR G Tardiff
Feb 8, 2003·Archives of Biochemistry and Biophysics·E A LukyanetzP G Kostyuk
Jun 19, 2004·The International Journal of Neuroscience·Eiki SatohMasakazu Nishimura

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Citations

Mar 8, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Joanna A RuszkiewiczMichael Aschner

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