Propylthiouracil-induced ANCA-positive erythema nodosum treated with thalidomide

International Journal of Dermatology
Pengjie WanJie Zheng

Abstract

Propylthiouracil (PTU), one of the mainstays of antithyroid therapy drugs, can lead to antineutrophil cytoplasmic antibody (ANCA) positivity and skin lesions. PTU-induced ANCA-positive vasculitis is rare and even more rare is erythema nodosum. To report a case of a 57-year-old woman with hyperthyroidism who developed myeloperoxidase (MPO)-ANCA erythema nodosum after PTU treatment for 11 months. Skin biopsy demonstrated septal panniculitis without vasculitis. PTU-induced ANCA-positive erythema nodosum was made. With discontinuation of PTU and initiation of thalidomide, skin lesions resolved completely in three weeks, and after three months, the titers of MPO-ANCA and perinuclear-ANCA (p-ANCA) had decreased remarkably. At 14-month follow-up, the patient was asymptomatic, but low levels of ANCA titers persisted. This report indicated that ANCA positive erythema nodosum could develop following PTU treatment. Thalidomide has been proven to be helpful and averted the adverse effects from systemic corticosteroids and other immunosuppressive drugs in this patient.

References

Jul 1, 1996·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·L BartalenaE Martino
May 9, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L HarperC O Savage
Aug 10, 1999·The Australasian Journal of Dermatology·T DarbenJ Chick
Oct 27, 1999·Journal of the American Academy of Dermatology·M A ChastainL E Millikan
Jan 15, 2000·Nihon rinsho. Japanese journal of clinical medicine·H Takizawa
Apr 27, 2000·The American Journal of Medicine·L Calabrese, A B Fleischer
Jun 5, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·Seok-Beom Hong, Mu-Hyoung Lee
Mar 5, 2005·Annales de dermatologie et de vénéréologie·A Boulenger-VazelB Sassolas
Oct 7, 2005·Arthritis Research & Therapy·Allan Wiik
Jul 15, 2006·Journal of Endocrinological Investigation·K GungorA Kaya
Oct 3, 2007·The Journal of Dermatology·Marumi SaitoFumio Kaneko
Jun 1, 2010·Dermatologic Clinics·Meng ChenSylvia Hsu

❮ Previous
Next ❯

Citations

Feb 27, 2016·International Journal of Dermatology·Clara De SimoneKetty Peris
Nov 28, 2013·Current Opinion in Rheumatology·William F Pendergraft, John L Niles

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Sriurai ThamprajamchitRajata Rajatanavin
Journal of the European Academy of Dermatology and Venereology : JEADV
Y KarincaogluB Mizrak
© 2022 Meta ULC. All rights reserved