Propylthiouracil-induced hypothyroidism protects ionizing radiation-induced multiple organ damage in rats

The Journal of Endocrinology
G SenerB C Yeğen

Abstract

The objective of this study was to examine the potential radioprotective properties of propylthiouracil (PTU)-induced hypothyroidism against oxidative organ damage induced by irradiation. Sprague-Dawley rats were pre-treated with saline or PTU (10 mg/kg i.p.) for 15 days, and were then exposed to whole-body irradiation (800 cGy). A group of rats were decapitated at 6 h after exposure to irradiation, while another group was followed for 72 h after irradiation, during which saline or PTU injections were repeated once daily. Lung, liver, kidney and ileum samples were obtained for the determination of malondialdehyde (MDA; an index of lipid peroxidation) and glutathione (GSH, an antioxidant) levels, myeloperoxidase activity (MPO; an index of tissue neutrophil accumulation) and collagen contents, while oxidant-induced DNA fragmentation was evaluated in the ileal tissues. All tissues were also examined microscopically and assayed for the production of reactive oxidants using chemiluminescence (CL). Lactate dehydrogenase (LDH), an indicator of tissue damage, and tumour necrosis factor-alpha (TNFalpha) were assayed in serum samples. Irradiation caused a significant decrease in GSH level, which was accompanied by significant increases i...Continue Reading

Citations

Jan 3, 2014·Antioxidants & Redox Signaling·Julie A ReiszCristina M Furdui
May 9, 2014·Radiation and Environmental Biophysics·Marina PeronaGuillermo J Juvenal
Jul 27, 2010·International Journal of Radiation Biology·Beste M AtasoyBerrak Ç Yeğen
Apr 24, 2012·General and Comparative Endocrinology·Srikanta JenaJagneshwar Dandapat
Aug 19, 2014·International Journal of Radiation Biology·Mona A El-GhazalyMohamed T Khayyal
Feb 13, 2013·Radiation Research·Marina PeronaGuillermo J Juvenal
Jun 11, 2010·Human & Experimental Toxicology·Ulvi DemirelHulya Aladag
Sep 1, 2018·Journal of Radiation Research·Anna LierovaZuzana Sinkorova
Sep 8, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mahmoud HosseiniFarimah Beheshti
Jun 17, 2019·Molecular Biology Reports·Khaled G Abdel-WahhabRehab F Taher

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