Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis

Internal Medicine
Rika TanakaYoshiki Sekijima

Abstract

We herein report a case of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) induced by propylthiouracil (PTU). A 30-year-old Japanese woman with Graves' disease, who was treated with PTU, reported with otitis media with sensorineural hearing loss bilaterally and trigeminal neuralgia on the left side, as well as elevated serum levels of myeloperoxidase-ANCA. Prior treatment with antibiotics was ineffective even after tympanostomy. However, clinical remission was immediately achieved after initiating prednisolone together with PTU withdrawal. These findings suggest that PTU therapy induces localized otological involvement as the concept of OMAAV.

References

Oct 3, 2000·Thyroid : Official Journal of the American Thyroid Association·N SeraK Eguchi
Sep 28, 2002·The Laryngoscope·Dai TakagiSatoshi Fukuda
Dec 8, 2004·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Masaki SanoRyutarou Kunikata
Mar 12, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Sriurai ThamprajamchitRajata Rajatanavin
Oct 8, 2008·Clinical Rheumatology·Muhammad Haroon, Joe Devlin
Jul 5, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Małgorzata WierzbickaAnna Bartochowska
Jul 5, 2012·Clinical and Experimental Nephrology·Koichi SugiyamaHirofumi Makino
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Mar 9, 2013·The American Journal of the Medical Sciences·Akio MoriNobutaka Hattori
Apr 15, 2014·Rheumatology·Eleana NtatsakiUNKNOWN BSR and BHPR Standards, Guidelines and Audit Working Group
Jul 9, 2014·Nature Reviews. Rheumatology·J Charles Jennette, Ronald J Falk
Oct 24, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Naohiro Yoshida, Yukiko Iino

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