PMID: 9422035Dec 1, 1995Paper

Prorenin and renal function in NIDDM patients with normo- and microalbuminuria

Journal of Internal Medicine
S NielsenC E Mogensen

Abstract

To assess whether prorenin is elevated and perhaps a predictor of deteriorations in albuminuria and/or renal function in NIDDM patients with normo- and microalbuminuria. A cross-sectional and a longitudinal study. Outpatient diabetic clinic. Twenty-eight NIDDM patients (16 with normoalbuminuria, 12 with microalbuminuric) and 16 healthy subjects, matched for sex, age and BMI. Fifteen patients were reinvestigated after (mean [range]) 3.1 (2.1-4.3) years. Serum prorenin and renin, urinary albumin excretion rate, and glomerular filtration rate. Serum prorenin was similar in both normoalbuminuric (116x/divided by) 1.9 microU ml-1 (geometric meanx/divided by antilog SD) and microalbuminuric (124x/divided by) 1.7 microU ml-1) as well as in healthy control subjects (90x/divided by) 1.7 microU ml-1). Prorenin did not correlate to either urinary albumin excretion rate or glomerular filtration rate. No difference between baseline and follow-up levels of albuminuria, glomerular filtration rate or prorenin were observed. The annual changes in albuminuria, glomerular filtration rate and prorenin were not correlated, and no correlation was found between baseline prorenin levels and annual changes in albuminuria or glomerular filtration rate. ...Continue Reading

References

Jun 17, 1978·Lancet·S R Tatemichi, D H Osmond
Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·A A FrankenM A Schalekamp
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T ShinagawaW A Hsueh
Oct 1, 1988·American Journal of Clinical Pathology·A ArizaE E Manuelidis
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·A H DanserM A Schalekamp
Feb 1, 1988·The Journal of Clinical Endocrinology and Metabolism·M Bryer-AshJ A Luetscher
May 30, 1985·The New England Journal of Medicine·J A LuetscherM Bryer-Ash
May 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·R J JarrettT J Murrells
Mar 1, 1983·The Journal of Clinical Endocrinology and Metabolism·M Bryer-AshJ A Luetscher
Feb 9, 1984·The New England Journal of Medicine·C E Mogensen
Jul 12, 1984·The New England Journal of Medicine·C E Mogensen, C K Christensen
Dec 30, 1993·The American Journal of Cardiology·W A Hsueh, P W Anderson

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