Proresolving Action of Docosahexaenoic Acid Monoglyceride in Lung Inflammatory Models Related to Cystic Fibrosis

American Journal of Respiratory Cell and Molecular Biology
Caroline MorinSamuel Fortin

Abstract

Cystic fibrosis (CF) is a hereditary, chronic disease of the exocrine glands, characterized by the production of viscid mucus that obstructs the pancreatic ducts and bronchi, leading to infection and fibrosis. ω3 fatty acid supplementations are known to improve the essential fatty acid deficiency as well as reduce inflammation in CF. The objective of this study was to determine the effects of docosahexaenoic acid monoacylglyceride (MAG-DHA) on mucin overproduction and resolution of airway inflammation in two in vitro models related to CF. Isolated human bronchi reverse permeabilized with CF transmembrane conductance regulator (CFTR) silencing (si) RNA and stable Calu3 cells expressing a short hairpin (sh) RNA directed against CFTR (shCFTR) were used. Lipid analyses revealed that MAG-DHA increased DHA/arachidonic acid (AA) ratio in shCFTR Calu-3 cells. MAG-DHA treatments, moreover, resulted in a decreased activation of Pseudomonas aeruginosa LPS-induced NF-κB in CF and non-CF Calu-3 cells. Data also revealed a reduction in MUC5AC, IL-6, and IL-8 expression levels in MAG-DHA-treated shCFTR cells stimulated, or not, with LPS. Antiinflammatory properties of MAG-DHA were also investigated in a reverse-permeabilized human bronchi mod...Continue Reading

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Citations

May 3, 2018·Physiological Reviews·Nandini KrishnamoorthyBruce D Levy
Jul 5, 2018·Cancer Metastasis Reviews·Milene Volpato, Mark A Hull
Sep 13, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Krithika Lingappan, Bhagavatula Moorthy
May 13, 2020·Cellular and Molecular Life Sciences : CMLS·Dušan GarićDanuta Radzioch
Jun 17, 2015·Biochemical and Biophysical Research Communications·Marcelo G BinkerLaura I Cosen-Binker

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