Pros and cons for use of statins in people with coronavirus disease-19 (COVID-19).

Diabetes & Metabolic Syndrome
Ray SubirGangopadhyay Kalyan K

Abstract

Morbidity and mortality from coronavirus disease 2019 (COVID-19) is higher among people with diabetes mellitus (DM), hypertension, and cardiovascular disease (CVD). Statins are used in the majority of people with DM and CVD. This mini-review discusses the current understanding of benefit-risk ratio of use of statins in COVID-19. We searched PubMed database using specific keywords related to our aims till June 12, 2020. Full text of relevant articles published in English language were retrieved and reviewed. Statins, with their immunomodulatory, anti-inflammatory, anti-thrombotic, and anti-oxidant properties, have the potential to reduce severity of lung injury in, and mortality from, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) infections. Statin-induced upregulation of angiotensin-converting enzyme-2 (ACE2) has the potential to reduce lung injury from excess angiotensin II. By disrupting lipid rafts, statins have the potential to reduce viral entry into cells. However, benefit-risk ratio of its complex interaction with MYD88 gene expression on outcomes in COVID-19, and the putative role of low serum LDL cholesterol in increasing severity of SARS-CoV2 infection need further clarification. People with COVID-19, wh...Continue Reading

Citations

Feb 2, 2021·Translational Medicine Communications·Payam PeymaniSaeid Ghavami
Jan 15, 2021·Viruses·Jerome E Tanner, Caroline Alfieri
Feb 23, 2021·International Reviews of Immunology·Yifan QueGuogang Xu
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Maurizio SoriceVincenzo Mattei
Apr 30, 2021·Progress in Lipid Research·Maria Chiara ProtoMaurizio Bifulco
May 7, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuji IkariShingo Matsumoto
Jun 22, 2021·Biochimie·Stéphane OrlowskiEric Bruckert
Jul 3, 2021·Life·Justyna Olszewska-ParasiewiczDariusz A Kosior
Aug 7, 2021·Journal of Cardiovascular Development and Disease·Nasim KiaieAmirhossein Sahebkar
Aug 20, 2021·Frontiers in Immunology·Jiao LiuDechang Chen

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