PMID: 3756186Oct 17, 1986Paper

Prosimian hemoglobins. III. The primary structures of the duplicated alpha-globin chains of Lemur variegatus

Biochimica Et Biophysica Acta
D H CoppenhaverL K Duffy

Abstract

The amino acid sequences of the alpha chains of hemoglobins purified from Lemur variegatus erythrocytes have been determined. The sequences were determined primarily from peptides generated from treatment of the isolated alpha chains with cyanogen bromide or warm formic acid. The ordering of the peptides from both alpha globins was based on the homology between lemur hemoglobins and those of other primates. The genetic difference at position 15 (Asn vs. Lys) explains the phenotypic characteristic of two hemoglobin species during alkaline electrophoresis. The function of certain residues is discussed in the context of other known sequences. The dispersion of the amino acid changes noted in lemur species falls mostly within the first 75 residues of the alpha chain (exons 1 and 2). The extent of divergence of the L. variegatus alpha-globin chains from the Lemur fulvus alpha globin is similar to that seen for the beta-globin chains of these species. This degree of separation (11-16 residues) is consistent with an extended period of independent evolution by these congeneric species after their divergence.

References

Jan 1, 1977·Annual Review of Biochemistry·A C WilsonT J White
Nov 29, 1974·Annals of the New York Academy of Sciences·P E Nute
Jan 1, 1974·Journal of Molecular Evolution·C H Langley, W M Fitch
Aug 15, 1971·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·P E Nute, B Sullivan
Jan 1, 1972·Folia primatologica; international journal of primatology·J Buettner-JanuschD Coppenhaver
Jul 6, 1968·Nature·J B CleggD J Weatherall
Jan 1, 1981·Progress in Biophysics and Molecular Biology·M Goodman
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E A ZimmerA C Wilson

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Citations

Jan 1, 1987·American Journal of Primatology·Lawrence K DuffyDorian H Coppenhaver
Oct 31, 1991·Biochemical and Biophysical Research Communications·C A Ladino, C M O'Connor

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