Prospective 10-year evaluation of hypobetalipoproteinemia in a cohort of 772 firefighters and cross-sectional evaluation of hypocholesterolemia in 1,479 men in the National Health and Nutrition Examination Survey I

Metabolism: Clinical and Experimental
C J GlueckP S Gartside

Abstract

Our specific aim in a 10-year prospective study of 772 Cincinnati firemen (predominantly aged 26 to 46 years) was to determine the prevalence, attributes, and etiology of persistent hypobetalipoproteinemia, defined by entry low-density lipoprotein cholesterol (LDLC) less than 75 mg/dL. A second specific aim was to cross-sectionally assess hypocholesterolemia (defined by total serum cholesterol [TC] < 130 mg/dL) in 1,314 white and 165 black men aged 26 to 46 years in the National Health and Nutrition Examination Survey (NHANES I). The 141 black and 631 white firemen had 4,973 person-years of follow-up time (median, 7.1 yr/man). Of 772 men, 44 (5.7%) had entry LDL levels less than 75 mg/dL; they had a mean follow-up time of 7.3 yr/man. Of these 44 men, there were 12 (1.8% of the cohort) with entry LDLC less than 75 mg/dL, and at least 67% of their follow-up LDLC levels were less than 75. Their mean entry TC and LDLC levels were low (130 and 58 mg/dL), mean triglyceride (TG) was low (63 mg/dL), and mean high-density lipoprotein cholesterol (HDLC) was high (60 mg/dL), LDLC remained at less than 75 mg/dL in 81% of their follow-up samples. Their mean entry and follow-up cholesterol and LDLC did not differ (P > .1, 130 v 133 mg/dL and...Continue Reading

Citations

Dec 9, 2010·Journal of Cardiovascular Medicine·Gregory A Sgueglia, Filippo Crea
Jan 23, 2013·Current Cardiology Reports·Rose Q DoGregory G Schwartz
Nov 13, 2004·Nature·Jürgen SoutschekHans-Peter Vornlocher
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·John C LaRosa
Mar 15, 2011·Journal of Lipid Research·Marija Tadin-StrappsLyndon J Mitnaul
Oct 22, 2003·Der Internist·G Wolfram
Apr 20, 2010·Therapeutic Advances in Cardiovascular Disease·Willibald Hochholzer, Robert P Giugliano
Feb 5, 2013·The American Journal of Cardiology·John C LaRosaScott M Wasserman
Apr 10, 2021·Acta Psychiatrica Scandinavica·Anoop SankaranarayananSrinivasan Tirupati
Jun 30, 2021·Journal of Occupational and Environmental Medicine·Jaron Ras, Lloyd Leach
Mar 17, 2009·Preventive Medicine·F A Tayie, C A Zizza

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.