Prospective analysis of circulating metabolites and endometrial cancer risk.

Gynecologic Oncology
Laure DossusHector C Keun

Abstract

Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 129 metabolites (acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexoses, and sphingolipids) were measured by liquid chromatography-mass spectrometry. Conditional logistic regression estimated the associations of metabolites with endometrial cancer risk. An analysis focusing on clusters of metabolites using the bootstrap lasso method was also employed. After adjustment for body mass index, sphingomyelin [SM] C18:0 was positively (OR1SD: 1.18, 95% CI: 1.05-1.33), and glycine, serine, and free carnitine (C0) were inversely (OR1SD: 0.89, 95% CI: 0.80-0.99; OR1SD: 0.89, 95% CI: 0.79-1.00 and OR1SD: 0.91, 95% CI: 0.81-1.00, respectively) associated with endometrial cancer risk. Serine, C0 and two sphingomyelins were selected by the lasso method in >90% of the bootstrap samples...Continue Reading

References

Jul 28, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kari HemminkiCharlotta Granström
Apr 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marc J GunterHoward D Strickler
Sep 11, 2008·Annals of Clinical Biochemistry·Stephanie E ReuterGianfranco Fornasini
Mar 13, 2009·Carcinogenesis·Susanne SchiffmannSabine Grösch
Jun 3, 2009·Archives of Physiology and Biochemistry·Susen BeckerRudolf Kaaks
Mar 17, 2010·Prostaglandins & Other Lipid Mediators·Paweł KnappJan Górski
Sep 17, 2010·Endocrine-related Cancer·Laure DossusRudolf Kaaks
Mar 23, 2011·Nature Medicine·Thomas J WangRobert E Gerszten
Mar 21, 2012·Critical Reviews in Oncology/hematology·Wederson M ClaudinoFazlul H Sarkar
Jun 26, 2012·The Journal of Clinical Endocrinology and Metabolism·Mia M GaudetMark E Sherman
May 24, 2013·International Journal of Clinical Oncology·Yutaka IhataFumiki Hirahara
Mar 13, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A FloegelH Boeing
Dec 4, 2014·The Lancet Oncology·Melina ArnoldIsabelle Soerjomataram
Jun 16, 2015·Molecules and Cells·Seokjae ParkEun-Kyoung Kim
Aug 5, 2015·International Journal of Cancer. Journal International Du Cancer·Magdalena StepienMazda Jenab
Mar 5, 2016·Pharmacological Reports : PR·Kamil BieniasHalina Car
Sep 17, 2016·Nature Reviews. Cancer·Ming Yang, Karen H Vousden
Jan 18, 2017·Cell Metabolism·Christopher B Newgard
Jun 28, 2017·IUBMB Life·María M Adeva-AndanyAna María Pedre-Piñeiro
Aug 2, 2017·Journal of Proteome Research·Marion CarayolSabina Rinaldi
Sep 25, 2017·Diabetologia·Sophie MolnosLeen M 't Hart
Oct 19, 2017·Journal of the National Cancer Institute·Joannie Lortet-TieulentAhmedin Jemal
Dec 14, 2017·Journal of Proteome Research·Jacopo TroisiMaurizio Guida
Jan 24, 2018·The Journal of Steroid Biochemistry and Molecular Biology·Tamara KnificTea Lanišnik Rižner
Mar 30, 2018·Frontiers in Endocrinology·Yannick Audet-DelageChantal Guillemette
Nov 18, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Isabelle SoerjomataramFreddie Bray
Mar 7, 2019·Nature Communications·Laura B L WittemansClaudia Langenberg
Apr 6, 2019·International Journal of Cancer. Journal International Du Cancer·Julie A SchmidtRuth C Travis
Sep 25, 2019·BMC Medicine·Mathilde HisSabina Rinaldi
Feb 23, 2020·International Journal of Molecular Sciences·Uma V MahajanMadhav Thambisetty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.