Prospective analysis of the safety and efficacy of percutaneous cryoablation for pT1NxMx biopsy-proven renal cell carcinoma

Cardiovascular and Interventional Radiology
Ronald RodriguezChristos S Georgiades

Abstract

Our objective was to determine the efficacy and safety of image-guided, percutaneous cryoablation for American Joint Committee on Cancer pT1ANxMx and pT1BNxMx biopsy-proven renal cell carcinoma (RCC). Computed tomography (CT)-guided, percutaneous cryoablation was used to treat 117 renal lesions in 113 consecutive patients with pT1NxMx RCC. All 117 ablations were included in the safety analysis, and complications were categorized according to Common Terminology Criteria for Adverse Events version 3.0 (CTCAE v3.0). Eighty-one lesions were biopsy-proven RCC and were included in the efficacy analysis. Technical success was defined as the "ice-ball" covering the entire lesion plus a minimum 5-mm margin. Efficacy was defined as complete lack of enhancement and continuous decrease in size on subsequent follow-up imaging studies. Technical success was 100%, with 15% of ablations requiring air or saline injection to prevent nontarget ablation. We recorded a 7% rate of clinically significant complications (CTCAE category≥2) and 0% mortality. Renal function was not adversely affected. Seventy percent of patients were discharged to home on the same day. Efficacy was 98.7% for a median follow-up of 67 weeks (range 7-172). For the subgroup o...Continue Reading

References

Apr 7, 2004·Japanese Journal of Clinical Oncology·Seiichiro OzonoUNKNOWN Japanese Society of Renal Cancer
Feb 14, 2007·The Journal of Urology·David A KunkleRobert G Uzzo
Mar 27, 2007·Urology·Kyle J WeldJaime Landman
Jun 2, 2007·The Lancet Oncology·Vincenzo FicarraWalter Artibani
Jul 7, 2007·Cancer Control : Journal of the Moffitt Cancer Center·Jason Hafron, Jihad H Kaouk
Jul 25, 2007·AJR. American Journal of Roentgenology·Ronald J ZagoriaPeter E Clark
Jun 14, 2008·The Journal of Urology·David S FinleyRalph V Clayman
Aug 2, 2008·Current Opinion in Urology·Raj K Goel, Jihad H Kaouk
Aug 30, 2008·Journal of Vascular and Interventional Radiology : JVIR·Christos S GeorgiadesRonald Rodriguez
Sep 20, 2008·The Journal of Urology·Paul L CrispenBradley C Leibovich
Sep 25, 2008·Journal of Endourology·Zeph Okeke, Benjamin R Lee
May 22, 2009·Journal of Endourology·John B MalcolmMichael D Fabrizio
Aug 18, 2009·The Journal of Urology·Steven C CampbellUNKNOWN Practice Guidelines Committee of the American Urological Association

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Citations

Nov 23, 2013·AJR. American Journal of Roentgenology·Xavier BuyAfshin Gangi
Jan 5, 2014·Cardiovascular and Interventional Radiology·Christos S Georgiades, Ron Rodriguez
Aug 31, 2012·Cardiovascular and Interventional Radiology·Christos GeorgiadesGeorge Netto
Jul 15, 2015·Journal of Endourology·Monzer ChehabJoseph Ciacci
Nov 19, 2013·Techniques in Vascular and Interventional Radiology·Christos Georgiades, Ronald Rodriguez
Jan 23, 2016·AJR. American Journal of Roentgenology·Haruyuki TakakiKoichiro Yamakado
Nov 9, 2015·Journal of Vascular and Interventional Radiology : JVIR·James X ChenS William Stavropoulos
Jul 24, 2015·AJR. American Journal of Roentgenology·Luke J Higgins, Kelvin Hong
Apr 5, 2015·Journal of Vascular and Interventional Radiology : JVIR·Michael R MoynaghThomas D Atwell
Jan 21, 2015·Nature Reviews. Clinical Oncology·David J Breen, Riccardo Lencioni
Feb 26, 2016·Abdominal Radiology·Nirav PatelDavid J Breen
Jul 21, 2016·Cardiovascular and Interventional Radiology·Bharat KakaralaChristos S Georgiades
Nov 12, 2016·Medical Oncology·Roberto Luigi CazzatoAfshin Gangi
Nov 22, 2016·The Cancer Journal·S Brandon Hancock, Christos S Georgiades
Sep 29, 2017·Expert Review of Clinical Pharmacology·Alessia MennittoGiuseppe Procopio
May 29, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Guoliang HaoPing Liang
Jan 15, 2014·Urologia·Alessandro CrestaniRoberto Salvioni
Apr 24, 2013·Nature Reviews. Urology·Arturo CastroRaymond J Leveillee
Aug 10, 2011·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Jonathan P Piccini, James P Daubert
Sep 8, 2011·BJU International·Georges-Pascal HaberInderbir S Gill
Jul 10, 2012·Current Opinion in Urology·Maria del Pilar LagunaJean J M C H de la Rosette
Sep 4, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sang Hyun ChoiKyung Won Kim
Jul 15, 2015·Deutsches Ärzteblatt International·Marc Regier, Felix Chun
Nov 19, 2020·Cardiovascular and Interventional Radiology·Yasuhiro UshijimaKousei Ishigami
Aug 26, 2019·La Presse médicale·Maud Nouri-NeuvilleFrançois H Cornelis

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