Prospective Assessment of Adenovirus Infection in Pediatric Kidney Transplant Recipients

Transplantation
Rachel M EngenAjit P Limaye

Abstract

Adenovirus infection is associated with graft dysfunction and graft loss in pediatric cardiac, lung, and liver transplants in prior retrospective studies, but data in pediatric kidney transplant recipients is limited. We conducted a prospective single-center cohort study of 75 consecutive pediatric kidney transplant recipients who underwent monthly screening for adenovirus viremia and symptom assessment for 2 years posttransplant. Adenovirus viremia was detected in 11 (14.7%) patients at a median onset of 173 days (interquartile range, 109-310 days) posttransplant, 6 (8%) had asymptomatic viremia, and 5 (6.7%) had symptomatic disease (2 with hematuria and 3 with an acute febrile respiratory illness). Viremic patients did not differ from nonviremic patients in age, immunosuppression management, or cytomegalovirus or Epstein-Barr virus serostatus, but were more likely to develop cytomegalovirus viremia during the first 2 years posttransplant. No patient had an increase in creatinine from baseline during the time of adenovirus viremia. In a Cox proportional hazards regression, subclinical adenovirus viremia was not associated with a faster time to a 30% decline in estimated glomerular filtration rate. Adenovirus infection is commo...Continue Reading

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Citations

May 23, 2019·Current Opinion in Infectious Diseases·Diana F Florescu, Erica J Stohs
Sep 13, 2019·Clinical Microbiology Reviews·Michael G Ison, Hans H Hirsch
Mar 30, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Thurid Ahlenstiel-Grunow, Lars Pape
May 31, 2019·Current Opinion in Organ Transplantation·Hannah H Nam, Michael G Ison
Dec 18, 2021·Seminars in Respiratory and Critical Care Medicine·Joseph P Lynch, Adriana E Kajon

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