Prospective assessment of EUS criteria for lymphadenopathy associated with rectal cancer

Gastrointestinal Endoscopy
Ferga GleesonMichael J Levy

Abstract

There are few data that assess the accuracy of echo characteristics for predicting lymph-node (LN) metastases in patients with rectal cancer. To identify nodal echo characteristics and size predictive of malignant infiltration and to determine if any combination of standard nodal criteria has sufficient predictive value to preclude FNA. Prospective uncontrolled study. Tertiary-referral hospital. Seventy-six patients (68% men) with untreated rectal cancer; 52 had visualized LNs. EUS-guided FNA. Evaluation of perirectal nodal morphology accuracy that corresponds to malignant cytology and identification of echo criteria, including LN size, to have sufficient predictive value to predict malignancy. Forty-three of 52 patients (83%) underwent FNA of a visualized LN. Nodal hypoechogenicity and short-axis length >or=5 mm were factors independently predictive of malignancy. The number of malignant nodal echo features per node did not distinguish benign from malignant pathology, except when all 4 features were present. Only 68% of malignant LN had >or=3 echo characteristics. An optimum LN short-axis or long-axis length cutoff value of 6 mm or 9 mm were 90% and 95% specific, respectively, for the presence of malignancy by receiver operati...Continue Reading

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Citations

Feb 6, 2010·World Journal of Gastroenterology : WJG·Taylan Kav, Yusuf Bayraktar
Aug 16, 2011·Gastrointestinal Endoscopy·Ferga C GleesonMichael J Levy
Dec 24, 2010·Gastrointestinal Endoscopy·Christian JürgensenUlrich Stölzel
Mar 31, 2009·Gastrointestinal Endoscopy·Paul Fockens
Jun 15, 2010·Gastrointestinal Endoscopy·Kanwar R GillMichael B Wallace

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