Abstract
To prospectively analyze patterns of failure in patients with head-and-neck squamous cell carcinoma treated with definitive high-precision radiotherapy with a focus on location of failure relative to target volume coverage. Sixty patients treated with three-dimensional conformal radiotherapy or intensity-modulated radiation therapy were included. Locoregional failure volume was defined on the planning data set at relapse, and dose received was analyzed by use of dose-volume histograms. Thirteen patients were deemed to have had locoregional failures, of which two did not have any viable tumor on salvage neck dissection, leaving eleven patients with proven persistent or recurrent locoregional disease. Of these, 9 patients had in-field failure, 1 marginal failure, and 1 both in-field and marginal failures. Overall, only 2 of 11 patients (18%) with relapse had any marginal failure. Of the 20 sites of locoregional failure, 15 (75%) were in-field and 5 (25%) marginal. Distant metastases were detected in 3 patients, whereas a second new primary developed in 3 others. With a median follow-up of 26 months (interquartile range, 18-31 months) for surviving patients, the 3-year local control, locoregional control, disease-free survival, an...Continue Reading
References
Jan 16, 2003·International Journal of Radiation Oncology, Biology, Physics·K S Clifford ChaoDaniel A Low
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Nancy LeeJeanne M Quivey
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vincent GrégoireHervé Reychler
Aug 7, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Barbara BusselsWalter Van den Bogaert
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Min YaoHenry T Hoffman
Dec 17, 2005·Head & Neck·Nancy LeeK S Clifford Chao
Apr 18, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vincent GrégoirePeter Levendag
Jun 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William M MendenhallJatinder R Palta
Nov 18, 2006·Head & Neck·Megan E DalyQuynh-Thu Le
Dec 7, 2006·American Journal of Clinical Oncology·Min YaoHenry T Hoffman
Feb 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Min YaoJohn M Buatti
Aug 8, 2007·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Gabriela StuderChristoph Glanzmann
Jan 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Gordon O SchoenfeldWilliam M Mendenhall
Oct 8, 2008·American Journal of Clinical Oncology·Carlo GrecoNancy Y Lee
Nov 26, 2008·Seminars in Radiation Oncology·Avraham Eisbruch, Vincent Gregoire
Dec 11, 2008·Radiation Oncology·C M van RijC R N Rasch
Jan 13, 2009·International Journal of Radiation Oncology, Biology, Physics·Aron PopovtzerAvraham Eisbruch
Feb 3, 2009·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Anthony M BersonSherif Heiba
Apr 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Jimmy J CaudellJames A Bonner
Jun 23, 2009·International Journal of Radiation Oncology, Biology, Physics·Megan E DalyDaniel T Chang
Jun 26, 2009·International Journal of Radiation Oncology, Biology, Physics·Sapna NangiaD Ghosh
Citations
Jun 15, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·E BaymanM Sen
Aug 6, 2014·British Journal of Cancer·P BalermpasE Fokas
Mar 15, 2016·International Journal of Radiation Oncology, Biology, Physics·Julie KjemsJeppe Friborg
Aug 3, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tejpal GuptaAnil D'Cruz
Dec 25, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eva M StoiberKristina Giske
Apr 19, 2015·Radiation Oncology·Brigida Costa FerreiraMaria do Carmo Lopes
Dec 18, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gustavo Nader MartaRachel Riera
Jan 22, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kyle WangBarton F Branstetter
Jun 1, 2013·The Oncologist·Dirk Van GestelVincent Gregoire