Prospective association of depression and phobic anxiety with changes in telomere lengths over 11 years

Depression and Anxiety
Shun-Chiao ChangOlivia I Okereke

Abstract

Although depression and anxiety have been associated with shorter telomeres in cross-sectional studies, the data regarding the prospective relations of depression and anxiety to accelerated telomere length shortening are limited and findings are mixed. We prospectively examined relations of baseline depression and phobic anxiety to subsequent 11-year change in relative leukocyte telomere lengths (LTLs). We selected 1,250 women from a subcohort of the Nurses' Health Study who provided blood specimens at both blood collections (1989-1990 and 2000-2001). Depression was defined by self-reported regular antidepressant use or presence of severe depressive symptoms; anxiety symptoms were assessed using the Crown-Crisp Experiential Index. Using quantitative real-time polymerase chain reaction assay, LTLs were measured as the copy number ratio of telomere repeat to a single control gene. Changes in LTLs were defined in three ways: absolute change, symmetrized percent change, and decile shift. Overall, there were no statistically significant associations of depression or phobic anxiety to subsequent 11-year LTL shortening, despite a point estimates in the direction of greater telomere shortening among participants with versus without dep...Continue Reading

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Citations

Apr 9, 2019·Depression and Anxiety·Jennifer Cai GillisOlivia I Okereke
May 31, 2019·Current Opinion in Psychiatry·Francesco S BersaniOwen M Wolkowitz
Apr 29, 2020·Journal of the International Neuropsychological Society : JINS·Adiba AshrafiLawrence S Honig
Apr 10, 2021·Scientific Reports·Angelica Cerveira de BaumontGisele G Manfro

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