Prospective association of liver function biomarkers with development of hepatobiliary cancers

Cancer Epidemiology
Magdalena StepienMazda Jenab

Abstract

Serum liver biomarkers (gamma-glutamyl transferase, GGT; alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; total bilirubin) are used as indicators of liver disease, but there is currently little data on their prospective association with risk of hepatobiliary cancers. A nested-case control study was conducted within the prospective EPIC cohort (>520,000 participants, 10 European countries). After a mean 7.5 mean years of follow-up, 121 hepatocellular carcinoma (HCC), 34 intrahepatic bile duct (IHBC) and 131 gallbladder and biliary tract (GBTC) cases were identified and matched to 2 controls each. Circulating biomarkers were measured in serum taken at recruitment into the cohort, prior to cancer diagnosis. Multivariable adjusted conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI). In multivariable models, 1SD increase of each log-transformed biomarker was positively associated with HCC risk (OR(GGT)=4.23, 95%CI:2.72-6.59; OR(ALP)=3.43, 95%CI:2.31-5.10;OR(AST)=3.00, 95%CI:2.04-4.42; OR(ALT)=2.69, 95%CI:1.89-3.84; OR(Bilirubin)=2.25, 95%CI:1.58-3.20). Each liver enzyme (OR(GGT)=4.98; 95%CI:1.75-14.17; OR(AST)=3.10, 95%CI:1.04-9.30; OR(A...Continue Reading

References

Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield
Apr 6, 2004·Clinics in Liver Disease·Flavia D Mendes, Keith D Lindor
Sep 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen D ZuckerKenneth E Sherman
Feb 3, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Edoardo G GianniniVincenzo Savarino
Jun 29, 2005·Diabetes Care·Monica NannipieriUNKNOWN Mexico City diabetes study
Nov 15, 2006·Clinical Oncology : a Journal of the Royal College of Radiologists·J M ChaS J Jang
Jul 31, 2008·World Journal of Gastroenterology : WJG·Asmaa-Ibrahim GomaaSimon-D Taylor-Robinson
Sep 22, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Jeong-Hoon LeeHyo-Suk Lee
Mar 5, 2010·Cleveland Clinic Journal of Medicine·George Aragon, Zobair M Younossi
Apr 14, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mieke Van HemelrijckLars Holmberg
Oct 25, 2011·Journal of the National Cancer Institute·Dimitrios TrichopoulosElio Riboli
Oct 18, 2012·Journal of the National Cancer Institute·Chi-Pang WenXifeng Wu
May 24, 2013·International Journal of Molecular Sciences·Isabella SaviniLuciana Avigliano
May 31, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S SchlesingerU Nöthlings
Oct 2, 2013·Nature Reviews. Gastroenterology & Hepatology·Gregory A MichelottiAnna Mae Diehl
Feb 25, 2014·Surgical Oncology Clinics of North America·Mathew M Augustine, Yuman Fong
May 3, 2014·Seminars in Oncology·Brian I CarrUNKNOWN Italian Liver Cancer (ITA.LI.CA) Group
Jul 22, 2014·International Journal of Cancer. Journal International Du Cancer·Setor K KunutsorGianluca Perseghin
Oct 23, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chi-Pang WenXifeng Wu

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Citations

Jan 21, 2017·Environmental Research·Marie PedersenOle Raaschou-Nielsen
Dec 9, 2017·BMC Gastroenterology·Nicha WongjarupongRoongruedee Chaiteerakij
Sep 27, 2018·International Journal of Veterinary Science and Medicine·O E Ola-DaviesM O Abatan
Oct 24, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Rui ChengYan-Ling Chen
Aug 1, 2020·International Journal of Cancer. Journal International Du Cancer·Magdalena StepienMazda Jenab
Feb 6, 2017·British Journal of Cancer·Magdalena StepienMazda Jenab
Apr 7, 2018·European Journal of Epidemiology·Rodolfo Saracci
Apr 24, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Joo-Hyun ParkJoo Kyung Park
Apr 27, 2021·International Journal of Cancer. Journal International Du Cancer·Ana-Lucia MayénHeinz Freisling

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