Prospective associations of depression with survival: a population-based cohort study in patients with newly diagnosed breast cancer

Breast Cancer Research and Treatment
Andrea VodermaierRobert Olson

Abstract

Psychological factors may influence survival in breast cancer patients but results of previous research are inconclusive. This prospective population-based study tested whether depression predicts mortality in breast cancer patients. Routinely collected depression screening data were merged with electronically archived provincial cancer registry data and censored data from British Columbia Vital Statistics (extracted in December 2012). Cox proportional-hazards regression analyses were conducted to predict all-cause and breast cancer-specific mortality as a function of depression after controlling for biomedical confounders. Of 1,646 patients, 1,604 had breast cancer stages I-III and 42 had stage IV breast cancer. 176 (11.0 %) versus 28 (66.7 %) were deceased after a median follow-up of 76 months. In patients with curable breast cancer, depression predicted all-cause (HR = 1.54 (95 % CI 1.06-2.25); p = 0.024), but not breast cancer-specific mortality (HR = 1.51 (95 % CI 0.95-2.41); p = 0.084). No association was shown for metastatic disease. Stage-specific analyses demonstrated a 2-2.5-fold increase in breast cancer-specific and all-cause mortality in patients with stage I and II disease, but not in patients with stage III or IV...Continue Reading

References

Oct 5, 1979·JAMA : the Journal of the American Medical Association·L R DerogatisN Melisaratos
Jan 1, 1987·Journal of Chronic Diseases·T G HislopL Kan
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
May 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J NixonJ R Harris
May 1, 1997·Psychosomatic Medicine·A van't SpijkerH J Duivenvoorden
Jan 8, 2003·Psychosomatics·Karen HjerlTorben Jørgensen
Dec 23, 2003·Journal of the American Geriatrics Society·James S GoodwinGlenn V Ostir
Oct 8, 2004·Critical Care : the Official Journal of the Critical Care Forum·Viv BewickJonathan Ball
Oct 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela J GoodwinNicky Hood
Nov 16, 2004·Psycho-oncology·Evaon C Wong-Kim, Joan R Bloom
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy E AvisJaneen Manuel
Aug 16, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M WatsonJudith M Bliss
Sep 8, 2005·Health and Quality of Life Outcomes·Wolfgang LindenRichard Doll
Nov 30, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G H de BockC J van de Velde
May 3, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wayne A BardwellJohn P Pierce
Sep 5, 2006·General Hospital Psychiatry·Adedayo A OnitiloLeonard E Egede
Jul 22, 2008·Brain, Behavior, and Immunity·Guillermo N Armaiz-PenaAnil K Sood
Oct 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kelly-Anne PhillipsRoger L Milne
Feb 26, 2009·Health and Quality of Life Outcomes·Wolfgang LindenRichard Doll
Oct 15, 2009·Journal of the National Cancer Institute·Andrea VodermaierChristopher Siu
Dec 25, 2009·European Journal of Cancer Care·A HinzR Schwarz
Jan 1, 2010·The Breast : Official Journal of the European Society of Mastology·Penelope HopwoodUNKNOWN START Trials Management Group
Jan 21, 2010·Psychological Medicine·M Pinquart, P R Duberstein
May 5, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Robert OlsonMichael McKenzie
Dec 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janine Giese-DavisDavid Spiegel
Jul 27, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C CluzeR Giorgi
Oct 7, 2011·Breast Cancer Research and Treatment·Uwe GüthSeraina Margaretha Schmid
Nov 19, 2011·British Journal of Cancer·A VodermaierC Marshall
Jun 13, 2012·Breast Cancer Research and Treatment·Caitlin C MurphySally W Vernon
Jun 26, 2012·Journal of Affective Disorders·Wolfgang LindenDuncan Greig
Apr 23, 2013·Acta Psychiatrica Scandinavica. Supplementum·M BerkF N Jacka

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Citations

Jan 6, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Juliane FarthmannA Hasenburg
Oct 1, 2015·Breast Cancer Research and Treatment·Annette L StantonKaren L Weihs
Jan 18, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nis P SuppliSusanne O Dalton
Jul 21, 2017·Cancer Nursing·Oxana PaleshCheryl Koopman
Oct 20, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Eun-Jung ShimJung Eun Lee
Feb 6, 2020·Breast Cancer Research and Treatment·Jingjing ZhuXiao-Ou Shu
Aug 21, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Bianca SenfJens Fettel
Dec 12, 2020·Future Oncology·Daniel C McFarlandChristian Nelson
Feb 2, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Fabio EfficaceMarco Vignetti
May 4, 2021·Psychosomatic Medicine·Jane WalkerMichael Sharpe

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