Prospective audit of conversion from regular to lispro insulin during routine clinical care

Internal Medicine Journal
H LuntM Cullens

Abstract

Randomized controlled trials show that lispro insulin has the potential to improve glycaemic control. Observational, practice-based studies provide information that is complementary to that obtained from randomized controlled trials and results of both types of studies are of relevance when advising patients of likely outcomes during routine clinical care. This prospective audit aimed to determine whether conversion from regular (short-acting, soluble) preprandial insulin to lispro during routine clinical care improved glycated haemoglobin. Eligible patients were those using regular insulin before main meals and a basal neutral protamine Hagedorn (NPH) insulin. Study group patients were those who chose to convert to lispro insulin. Patients who elected not to change their regimen were used as a comparison group. Follow up was for a minimum of 1 year. Glycated haemoglobin (HbA(1c)) and body mass index showed no change in either the study or comparison groups. Post-hoc analysis revealed that the patients most likely to improve their HbA(1c) on lispro were those with a higher baseline HbA(1c). Patients using lispro reported a decreased frequency of hypoglycaemia and improved convenience of use. Administration of lispro insulin was...Continue Reading

References

May 18, 1999·The Medical Journal of Australia·A E Stocks
May 23, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·N KongR E Ryder
Oct 26, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·P D Home
Mar 29, 2002·Diabetes/metabolism Research and Reviews·Sten Madsbad
May 23, 2002·Clinical Therapeutics·John H HolcombeUNKNOWN Lispro in Adolescents Study Group
Oct 22, 2002·Nihon rinsho. Japanese journal of clinical medicine·Ayako Matsuda
Oct 31, 2002·PharmacoEconomics·Christopher J Dunn, Greg L Plosker

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Citations

Mar 31, 2007·Seminars in Thoracic and Cardiovascular Surgery·Susan S Braithwaite
Nov 23, 2005·Pediatric Clinics of North America·Marianna RachmielDenis Daneman

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