PMID: 8583583Mar 1, 1996Paper

Prospective characterization of pathological features of prostatic carcinomas detected via serum prostate specific antigen based screening

The Journal of Urology
P A HumphreyWilliam J Catalona

Abstract

Many small (less than 0.5 cc), well differentiated, organ-confined prostate carcinomas remain clinically undetected during the life of the patient and are identified only at postmortem examination. Thus, these cancers are often called latent or autopsy cancers. There is concern that serum prostate specific antigen (PSA) based screening may preferentially detect these cancers. There are limited prospective data concerning the pathological features of carcinomas of the prostate detected in a screening program. We determined if prostatic carcinomas detected via PSA based screening resembled autopsy cancers. We assessed the pathological features of carcinomas in 100 consecutive, completely embedded radical prostatectomy specimens from men whose cancer was detected in a PSA based screening program. The tumors were evaluated for pathological stage, surgical margin status, Gleason histological grade and intraglandular tumor extent (morphometrically quantified as percentage carcinoma and tumor volume). Of 100 carcinomas 68 (68%) were larger than 0.5 cc in volume (mean 1.7, range 0.1 to 10.7). Mean amount of carcinoma in the surgical specimen was 10.3% (range 0.1 to 41.6). Of the 100 carcinomas 94 had a Gleason score of 5 to 8 (mean 5.7...Continue Reading

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Citations

Jan 1, 1997·Urological Research·O Haillot, P Perrin
Jan 1, 1997·World Journal of Urology·H B Carter, J I Epstein
Nov 20, 2003·Urology·Masood A KhanH Ballentine Carter
Jan 1, 1997·Urology·P I KarakiewiczM M Elhilali
May 1, 1997·The Urologic Clinics of North America·C G ArcangeliG L Andriole
Sep 24, 2002·International Journal of Radiation Oncology, Biology, Physics·Anthony V D'AmicoJerome P Richie
Sep 1, 2005·Prostate Cancer and Prostatic Diseases·M A Khan, A W Partin
Apr 29, 1998·The Journal of Urology·G D SteinbergC B Brendler
Apr 1, 1997·Journal of Clinical Pathology·M R Feneley, M C Parkinson
Sep 11, 2002·American Journal of Clinical Pathology·James S LewisPeter A Humphrey
Jun 5, 2013·Annals of Internal Medicine·Ruth EtzioniJeanne Mandelblatt
May 15, 1998·Mayo Clinic Proceedings·P A Humphrey
Jan 12, 2007·Annales D'urologie·C Seitz, B Djavan
Jun 1, 1997·The Journal of Urology·H B CarterJ I Epstein
Mar 31, 2004·The Medical Clinics of North America·Misop HanWilliam J Catalona

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