Prospective clinical and radiologic evaluation of patellofemoral matrix-induced autologous chondrocyte implantation

The American Journal of Sports Medicine
Jay R EbertDavid J Wood

Abstract

While matrix-induced autologous chondrocyte implantation (MACI) has demonstrated encouraging outcomes in the treatment of knee chondral defects, there remains little available research specifically investigating its use in the patellofemoral joint. To prospectively evaluate the clinical and radiologic outcome of MACI in the patellofemoral joint. Case series; Level of evidence, 4. In 47 consecutive patients undergoing patellofemoral MACI, clinical (Knee injury and Osteoarthritis Outcome Score, 36-Item Short Form Health Survey, visual analog scale for pain, 6-minute walk test, knee range of motion, and strength assessment) and magnetic resonance imaging (MRI) assessments were undertaken before and 3, 12, and 24 months after surgery. The MRI was performed to assess graft infill and determine an overall MRI composite score. Results were analyzed according to (1) the patient sample overall and (2) after stratification into 4 subgroups per implant location (patella or trochlea) as well as whether or not adjunct tibial tubercle transfer for patellofemoral malalignment was required. The overall patient sample, as well as each of the 4 procedural subgroups, demonstrated clinically and statistically significant (P < .05) improvements ove...Continue Reading

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Citations

May 11, 2016·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Alex C DiBartolaDavid C Flanigan
Jun 4, 2016·BMC Musculoskeletal Disorders·Xing ZhaoMark A Randolph
Aug 20, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Aaron J KrychRiley J Williams
Jan 4, 2020·The American Journal of Sports Medicine·Betina B HinckelSeth L Sherman
Jul 13, 2019·Nature Reviews. Rheumatology·Heenam KwonKyriacos A Athanasiou
Apr 14, 2017·The Journal of the American Academy of Orthopaedic Surgeons·Robert H BrophyJoseph D Lamplot
Sep 21, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Ajaykumar ShanmugarajOlufemi R Ayeni
Dec 4, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Edna IordacheMichael T Hirschmann
Apr 24, 2021·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Yoshikazu SumidaRainer Siebold
Jul 1, 2021·Current Research in Translational Medicine·Theofanis StampoultzisDominique P Pioletti
Sep 3, 2021·Journal of Orthopaedic Surgery and Research·Filippo MiglioriniNicola Maffulli
Sep 24, 2021·British Medical Bulletin·Filippo MiglioriniNicola Maffulli

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

Stata
MOCART
IC

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