Prospective clinical trial of the feasibility and safety of modified retroperitoneal lymph node dissection at time of nephroureterectomy for upper tract urothelial carcinoma

BJU International
Sandhya R RaoPhilippe E Spiess

Abstract

What's known on the subject? and What does the study add? Very little is known about the safety and potential oncological benefit of performing a retroperitoneal lymph node dissection at time of nephroureterectomy for upper tract tumours. This study is the first clinical trial to prospectively validate the safety and feasibility of a retroperitoneal lymph node dissection at time of nephroureterectomy for upper tract tumours. The onus is now on the scientific community at large to conduct adequately powered multicentre clinical trials to evaluate the potential oncological benefit it may impart to patients with upper tract tumours. • To determine the safety and feasibility of modified retroperitoneal lymph node dissection (RPLND) at the time of radical nephroureterectomy (RNU). • Between 2009 and 2011, 20 patients with suspected upper urinary tract urothelial carcinoma (UUT-UC) underwent open (n= 10), laparoscopic (n= 4), or robot-assisted (n= 6) RNU with modified RPLND. • Demographic, clinical and pathological data, histological nodal status, peri-operative complications and recurrence data were collected. • On histopathological review, one patient had a benign angioma and was excluded from the final data analysis. Of the remain...Continue Reading

References

Mar 1, 1995·The Journal of Urology·J BanielJ P Donohue
Feb 5, 1998·CA: a Cancer Journal for Clinicians·S H LandisP A Wingo
Oct 3, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M OzsahinR O Mirimanoff
Jun 18, 2004·The Journal of Urology·Mohamed Abdel-LatifMohamed A Ghoneim
Jan 4, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Fernando P SecinBernard H Bochner
Jul 14, 2010·The Journal of Urology·Vitaly MargulisUNKNOWN Upper Tract Urothelial Carcinoma Collaborative Group
Sep 14, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T AbeK Nonomura

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Citations

Jun 23, 2015·The Journal of Urology·Surena F MatinPhilippe E Spiess
Jul 24, 2015·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Tian ZhangBaiyong Shen
Jan 13, 2015·The Journal of Orthopaedic and Sports Physical Therapy·Andrew P HawkinsSoma Sahai-Srivastava
Dec 7, 2016·Japanese Journal of Clinical Oncology·Hiroshi FuruseSeiichiro Ozono
Oct 6, 2018·Indian Journal of Surgical Oncology·Ashwin Sunil TamhankarGagan Gautam
Aug 11, 2019·Journal of Clinical Medicine·Igor DuquesneEvanguelos Xylinas

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