Prospective cohort studies of beta-trace protein and mortality in haemodialysis patients and patients undergoing coronary angiography

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Dietmar EnkoRainer P Woitas

Abstract

Beta-trace protein (BTP) is a low-molecular-weight glycoprotein, which may serve as an endogenous biomarker of kidney function and cardiovascular risk. We examined cardiovascular and all-cause mortality according to BTP concentrations in 2962 individuals referred for coronary angiography from the Ludwigshafen Risk and Cardiovascular Health study and in 907 patients with Type 2 diabetes mellitus undergoing haemodialysis from the German Diabetes and Dialysis (4D) study. Haemodialysis patients had considerably higher median (interquartile range) BTP concentrations [6.00 (4.49-7.96) mg/L] and experienced a 4-fold increased mortality rate compared with coronary angiography patients [BTP concentration: 0.55 (0.44-0.67) mg/L]. After adjustment for age, sex, cardiovascular risk factors and creatinine, 4D patients in the highest quartile (>7.96 mg/L) had a 1.6-fold increased rate of all-cause mortality [hazard ratio (HR) 1.62, 95% confidence interval (CI) 1.19-2.20] compared with the lowest quartile (<4.49 mg/L) (P = 0.002) In patients undergoing coronary angiography, the adjusted HRs (95% CI) for all-cause and cardiovascular mortality were 1.23 (1.0-1.51) and 1.27 (0.99-1.63) in the highest (>0.67 mg/L) compared with the lowest (<0.44 ...Continue Reading

References

Mar 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·G M HochwaldG J Thorbecke
Jul 14, 2000·Physiological Reviews·M Wyss, R Kaddurah-Daouk
Mar 22, 2001·Pharmacogenomics·B R WinkelmannUNKNOWN LURIC Study Group (LUdwigshafen RIsk and Cardiovascular Health)
Oct 29, 2003·Circulation·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Aug 19, 2004·Kidney & Blood Pressure Research·Christoph WannerUNKNOWN Deutsche Diabetes-Dialyse-Studie (4D) Study Group
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Oct 4, 2005·Journal of the American College of Cardiology·Peter Libby
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Aug 25, 2010·Circulation·Winfried MärzChristoph Wanner
Jun 30, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Tariq ShafiJosef Coresh
Jan 19, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adrienne TinW H Linda Kao
Jan 22, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Esteban Orenes-PiñeroJames L Januzzi
Mar 20, 2013·Current Opinion in Nephrology and Hypertension·Brad C AstorMuhammad Chaudhry
May 17, 2014·Clinical Biochemistry·Guido FillerMarta Kobrzyński
Dec 3, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Christine A WhiteMichael A Adams
Sep 13, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A InkerAndrew S Levey

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