Prospective cohort study of C-reactive protein as a predictor of clinical events in adults with congenital heart disease: results of the Boston adult congenital heart disease biobank

European Heart Journal
Alexander R OpotowskyMichael J Landzberg

Abstract

Despite the well-defined association of high-sensitivity hsCRP with cardiovascular outcomes in apparently healthy adults and those with acquired heart disease, the relevance of this inflammatory marker in adults with congenital heart disease (ACHD) remains unclear. We aimed to examine the clinical correlates and prognostic value of high-sensitivity C-reactive protein levels in ACHD. We conducted a prospective cohort study of (n = 707) outpatient ACHD (age 39 ± 14 years, 49% women), enrolled mainly at a referral centre, who had serum hsCRP measured in conjunction with a clinical assessment between 2012 and 2016. We analysed clinical correlates of hsCRP and its association with adverse events including the primary combined outcome of all-cause mortality or non-elective cardiovascular hospitalization. Higher hsCRP was strongly associated with measures of functional status including New York Heart Association class and peak V̇O2, and with comorbidities such as atrial arrhythmia. During average follow-up of 815 ± 536 days, 114 patients (16%) experienced the primary outcome, including 29 deaths. Having elevated hsCRP, in the highest (≥2.98 mg/L) compared with the lower three quartiles, conferred increased risk for the primary outcome...Continue Reading

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Citations

Jun 27, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hui-Hui LiuJian-Jun Li
May 20, 2020·Therapeutic Advances in Chronic Disease·Miriam MichelKai Thorsten Laser
Aug 23, 2019·Journal of the American Heart Association·Laurie W GeenenJolien W Roos-Hesselink
Dec 16, 2019·JACC. Heart Failure·Jonathan N MenachemJoAnn Lindenfeld
Jan 22, 2020·International Journal of Cardiology·Anita SarafWendy Book
Apr 1, 2019·European Heart Journal·Thomas F Lüscher
Apr 1, 2021·Journal of the American Heart Association·Adam M LubertAlexander R Opotowsky
Dec 3, 2021·Heart Failure Reviews·Laura M WieneckeBenjamin G Chousterman

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