Abstract
Despite the well-defined association of high-sensitivity hsCRP with cardiovascular outcomes in apparently healthy adults and those with acquired heart disease, the relevance of this inflammatory marker in adults with congenital heart disease (ACHD) remains unclear. We aimed to examine the clinical correlates and prognostic value of high-sensitivity C-reactive protein levels in ACHD. We conducted a prospective cohort study of (n = 707) outpatient ACHD (age 39 ± 14 years, 49% women), enrolled mainly at a referral centre, who had serum hsCRP measured in conjunction with a clinical assessment between 2012 and 2016. We analysed clinical correlates of hsCRP and its association with adverse events including the primary combined outcome of all-cause mortality or non-elective cardiovascular hospitalization. Higher hsCRP was strongly associated with measures of functional status including New York Heart Association class and peak V̇O2, and with comorbidities such as atrial arrhythmia. During average follow-up of 815 ± 536 days, 114 patients (16%) experienced the primary outcome, including 29 deaths. Having elevated hsCRP, in the highest (≥2.98 mg/L) compared with the lower three quartiles, conferred increased risk for the primary outcome...Continue Reading
References
Jan 20, 1999·Circulation·W KoenigM B Pepys
Mar 25, 2000·The New England Journal of Medicine·P M RidkerN Rifai
Apr 13, 2001·Journal of the American College of Cardiology·C A WarnesG D Webb
Dec 17, 2004·The New England Journal of Medicine·Jennifer K PaiEric B Rimm
Apr 7, 2005·JAMA : the Journal of the American Medical Association·Caroline KistorpPer Hildebrandt
Oct 12, 2005·Annals of Epidemiology·Hylton V JoffeKathryn M Rexrode
Aug 23, 2006·American Heart Journal·Susan G LakoskiDavid M Herrington
Mar 31, 2009·Lancet·Paul M RidkerUNKNOWN JUPITER Trial Study Group
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Oct 9, 2009·The Canadian Journal of Cardiology·Jacques GenestEhud Ur
Dec 25, 2009·Lancet·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
Mar 1, 2012·Circulation. Heart Failure·Bonnie KyThomas P Cappola
Mar 9, 2013·JAMA : the Journal of the American Medical Association·Jared M O'LearyAlexander R Opotowsky
Nov 14, 2013·Journal of the American Pharmacists Association : JAPhA
Nov 19, 2013·Journal of the American College of Cardiology·Neil J StoneUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines
May 3, 2014·Heart·Giancarlo ScognamiglioStephen J Wort
Mar 10, 2015·International Journal of Cardiology·Jannet A EindhovenEric Boersma
Jan 13, 2016·Journal of the American Heart Association·Alexander R OpotowskyMichael J Landzberg
Nov 1, 2016·Heart and Vessels·Kenji MiyamotoToshio Nakanishi
Feb 13, 2016·Journal of the American College of Cardiology·Paul M Ridker
May 26, 2016·European Heart Journal·Massimo F PiepoliUNKNOWN ESC Scientific Document Group
Jul 7, 2016·Circulation·Suzanne M GilboaAriane J Marelli
Aug 28, 2016·European Heart Journal·Alberico L CatapanoUNKNOWN ESC Scientific Document Group
Nov 11, 2016·Circulation·Vivan J M BaggenJolien W Roos-Hesselink
Nov 12, 2016·World Journal for Pediatric & Congenital Heart Surgery·Alexander R OpotowskyMichael J Landzberg
Aug 29, 2017·The New England Journal of Medicine·Paul M RidkerUNKNOWN CANTOS Trial Group
Sep 25, 2017·Heart·Vivan J M BaggenJolien W Roos-Hesselink
Citations
Apr 29, 2020·Journal of the American Heart Association·Matthew R CarazoAlexander R Opotowsky
Sep 12, 2018·European Heart Journal·Thomas F Lüscher
Jun 27, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hui-Hui LiuJian-Jun Li
May 20, 2020·Therapeutic Advances in Chronic Disease·Miriam MichelKai Thorsten Laser
Aug 23, 2019·Journal of the American Heart Association·Laurie W GeenenJolien W Roos-Hesselink
Dec 16, 2019·JACC. Heart Failure·Jonathan N MenachemJoAnn Lindenfeld
Jan 22, 2020·International Journal of Cardiology·Anita SarafWendy Book
Apr 1, 2019·European Heart Journal·Thomas F Lüscher
Mar 9, 2021·Journal of cardiology·Laura WillingerJan Müller
Oct 17, 2020·Heart·Laurie W GeenenEric Boersma
Apr 1, 2021·Journal of the American Heart Association·Adam M LubertAlexander R Opotowsky
Sep 7, 2021·Journal of the American Heart Association·Cara L LachtruppAlexander R Opotowsky
Dec 3, 2021·Heart Failure Reviews·Laura M WieneckeBenjamin G Chousterman