Prospective cohort study on the outcomes of hepatitis C virus-related cirrhosis in South Korea

Journal of Gastroenterology and Hepatology
Sang Soo LeeChun Kang

Abstract

The outcomes of hepatitis C virus (HCV)-related liver cirrhosis was limitedly studied in a hepatitis B virus-endemic area. This multicenter, prospective cohort study was conducted to elucidate the incidence of hepatocellular carcinoma (HCC) and mortality in the Korean patients with HCV-related cirrhosis. From January 2007 through June 2012, 196 patients with HCV-related cirrhosis were prospectively enrolled and regularly followed at six university hospitals to determine HCC occurrence and mortality. A multivariable analysis using Cox proportional hazards regression was performed to clarify the related factors to the outcomes. During a mean follow-up period of 39.2 months, 31 (15.8%) patients developed HCC, and 33 (16.8%) patients died or underwent liver transplantation. The estimated HCC incidence was 5.8 per 100 person-years, and the independent factors for HCC were absence of anti-HBV surface antibody (HBs hazard ratio [HR], 5.018; 95% confidence interval [CI], 1.710-14.726; P = 0.003) and serum albumin < 3.8 g/dL (HR, 3.051; 95% CI, 1.318-7.067; P = 0.009). The overall mortality rate was 5.1 per 100 person-years, and the related independent factors were the presence of ascites (HR, 2.448; 95% CI, 1.142-5.210; P = 0.022), ser...Continue Reading

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Citations

Apr 6, 2016·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
Aug 5, 2017·Epidemiology and Health·Sook-Hyang JeongMoran Ki
Jul 13, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Kyung-Ah KimSook-Hyang Jeong
Nov 22, 2018·Journal of Gastroenterology and Hepatology·Wankyo ChungSook-Hyang Jeong

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