Prospective cohort trial to confirm the efficacy of no-touch radio frequency ablation

Journal of Gastroenterology and Hepatology
Masashi HirookaYoichi Hiasa

Abstract

The aim of the present prospective study was to evaluate tumor recurrence (intrasubsegmental recurrence-free survival and local tumor recurrence-free survival) and hepatic functional reserve following no-touch ablation. The prospective cohort study protocols were approved by the institutional ethics committee. All patients provided written, informed consent. Between January 2014 and September 2016, 231 patients with 277 hepatocellular carcinoma nodules were prospectively enrolled. An internally cooled bipolar electrode was used for no-touch ablation, while a monopolar electrode was used for direct puncture ablation. The intrasubsegmental recurrence-free survival rate was the primary end-point. The secondary outcomes were the local recurrence-free survival rate, the disease-free survival rate, and the changes in the Child-Pugh score. No-touch ablation resulted in significantly higher cumulative intrasubsegmental tumor recurrence-free survival rates than direct puncture ablation (98.0% vs 87.1% at 1 year, 96.9% vs 76.8% at 2 years, and 91.0% vs 68.3% at 3 years, P < 0.001). The no-touch group also showed significantly better local recurrence-free survival and disease-free survival. Even when only primary cases were analyzed, the ...Continue Reading

References

Aug 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T TanakaE Okamoto
Apr 25, 2006·AJR. American Journal of Roentgenology·Masashi HirookaMorikazu Onji
Jul 9, 2009·Journal of Vascular and Interventional Radiology : JVIR·John F CardellaUNKNOWN Society of Interventional Radiology
Oct 12, 2012·Journal of Gastroenterology·Yukio OsakiKiwamu Okita
Mar 22, 2014·Molecular and Clinical Oncology·Masashi HirookaYoichi Hiasa
Jul 17, 2016·Journal of Hepatology·Arnaud HocqueletOlivier Seror
Aug 12, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masashi HirookaYoichi Hiasa
Feb 28, 2017·Journal of Gastroenterology and Hepatology·Masashi HirookaYoichi Hiasa

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