PMID: 16644608Apr 29, 2006Paper

Prospective comparative switch study from timolol 0.5% and latanoprost 0.005% to bimatoprost 0.03%

Advances in Therapy
Christopher J BrittainAndrew Waldock

Abstract

This prospective study compared intraocular pressure (IOP) control, cardiorespiratory function, and adverse effects in 50 patients with glaucoma and ocular hypertension. Patients on topical combination timolol-latanoprost therapy were recruited. After they had used this combination for at least 2 months, they were switched to bimatoprost monotherapy. Full ocular examination and spirometric testing were performed; a questionnaire concerned with ocular symptoms was completed, and pulse rate was recorded. Two months later, mean IOP was similar with the combination (17.2 mm Hg) and with bimatoprost (16.4 mm Hg), but mean peak expiratory flow rate, ratio of forced expiratory volume in 1 second to forced vital capacity, and heart rate had increased significantly after the switch was made to bimatoprost. Adverse effects generally were similar with these regimens; however, the incidence of hyperemia doubled after the switch had been made. Bimatoprost and the timolol-latanoprost combination were equally efficacious in lowering IOP; bimatoprost had less of an effect on cardiorespiratory function.

References

Nov 1, 1984·Ophthalmology·M S PassoE M Van Buskirk

❮ Previous
Next ❯

Citations

Oct 29, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Antônio Carlos FacioRemo Susanna
Oct 30, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Augusto ParanhosClaudio Luiz Lottenberg
Jan 29, 2013·Prostaglandins & Other Lipid Mediators·Iwona DamsAndrzej Kutner
Dec 17, 2008·Survey of Ophthalmology·Albert AlmM Bruce Shields

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.