PMID: 376098May 1, 1979Paper

Prospective comparison of intralesional and multipuncture BCG in recurrent intradermal melanoma

Cancer
L NathansonA Mittelman

Abstract

Fifty-nine patients with metastatic melanoma predominantly localized in the skin were randomly assigned to treatment with BCG given either intralesionally (IL-BCG) or by multiple puncture vaccination at a nontumor bearing site in the skin (MPV-BCG). Half the patients with IL-BCG experienced moderate fever, chills and malaise, suggesting systemic exposure to this live organism. However, only three of these patients required systemic antituberculous chemotherapy and all responded to it. MPV-BCG treated patients experienced significantly less systemic toxicity. Among fully evaluable patients 45% objective response rate was seen in the IL-BCG group and a 9% response rate in the MPV-BCG group, a significant difference. The only complete responses were seen in the IL-BCG group. Among fully evaluable patients, median survival was 21.1 months in the IL-BCG group and 13.3 months in the MPV-BCG groups (NSD). No patients with pretreatment anergy to all skin tests utilized, experienced objective response to BCG.

References

Sep 1, 1977·Cancer·M E CostanzaN Sedransk
Mar 1, 1978·Cancer·J A NortonS A Rosenberg
Oct 18, 1973·The New England Journal of Medicine·F C SparksD L Morton

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Citations

Mar 2, 2011·Cancer Biotherapy & Radiopharmaceuticals·Robert O Dillman
Nov 1, 1993·The Journal of Dermatologic Surgery and Oncology·J K Tan, V C Ho
Jun 1, 1979·Journal of Cutaneous Pathology·L Nathanson
Jan 1, 1985·Medical and Pediatric Oncology·H K KohR W Carey
Jan 1, 1984·Critical Reviews in Oncology/hematology·R V Smalley, R K Oldham
Feb 13, 2015·Clinical Nuclear Medicine·Steven M SoggeMark Tulchinsky
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel E SprattChristopher A Barker
May 19, 2000·British Journal of Cancer·A G Dalgleish

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