Prospective comparison of severity scores for predicting clinically relevant outcomes for patients hospitalized with community-acquired pneumonia

Chest
Pedro Pablo España YandiolaAntonio Torres

Abstract

The comparative accuracy and discriminatory power of three validated rules for predicting clinically relevant outcomes other than mortality in patients hospitalized with community-acquired pneumonia (CAP) are unknown. We prospectively compared the newly developed severe community-acquired pneumonia (SCAP) score, pneumonia severity index (PSI), and the British Thoracic Society confusion, urea > 7 mmol/L, respiratory rate > or = 30 breaths/min, BP < 90 mm Hg systolic or < 60 mm Hg diastolic, age > or = 65 years (CURB-65) rule in an internal validation cohort of 1,189 consecutive adult inpatients with CAP from one hospital and an external validation cohort of 671 consecutive adult inpatients from three other hospitals. Major adverse outcomes were admission to ICU, need for mechanical ventilation, progression to severe sepsis, or treatment failure. Mean hospital length of stay (LOS) was also evaluated. The rules were compared based on sensitivity, specificity, and area under the curve (AUC) of the receiver operating characteristic. The rate of all adverse outcomes and hospital LOS increased directly with increasing SCAP, PSI, or CURB-65 scores (p < 0.001) in both cohorts. Patients classified as high risk by the SCAP score showed hi...Continue Reading

References

Jan 23, 1997·The New England Journal of Medicine·M J FineW N Kapoor
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Derek C AngusWishwa N Kapoor
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
May 24, 2003·The European Respiratory Journal·P P EspañaA Bilbao
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alberto CapelasteguiAmaia Bilbao
Apr 6, 2005·The American Journal of Medicine·Drahomir AujeskyMichael J Fine
Dec 28, 2005·The American Journal of Medicine·Robert E Siegel
Dec 28, 2005·The American Journal of Medicine·Thomas J Marrie, Jane Q Huang
Jan 3, 2006·The European Respiratory Journal·A CapelasteguiA Bilbao
Jun 15, 2006·The European Respiratory Journal·A V KamathB D W Harrison
Sep 16, 2006·American Journal of Respiratory and Critical Care Medicine·Pedro P EspañaJosé M Quintana
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lionel A MandellUNKNOWN American Thoracic Society
Sep 29, 2007·Critical Care Medicine·Stijn I BlotUNKNOWN Community-Acquired Pneumonia Intensive Care Units (CAPUCI) Study Investigators
Oct 16, 2007·Chest·Rosario Menendez, Antoni Torres
Jun 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick G P CharlesM Lindsay Grayson

❮ Previous
Next ❯

Citations

Nov 17, 2010·Intensive Care Medicine·Santiago EwigAntoni Torres
May 3, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T Welte
Feb 5, 2013·Current Infectious Disease Reports·Stefano AlibertiFrancesco Blasi
Aug 21, 2009·International Journal of Clinical Practice·P K MyintA V Kamath
Sep 29, 2011·International Journal of Clinical Practice·O Ochoa-GondarJ Blade
Aug 31, 2010·American Journal of Respiratory and Critical Care Medicine·Ognjen GajicMichael Malinchoc
Mar 15, 2011·BMC Infectious Diseases·Ji Ye JungYoung Ae Kang
Mar 16, 2011·Critical Care : the Official Journal of the Critical Care Forum·Nesrin O Ghanem-ZoubiHaim Bitterman
Jan 21, 2011·Critical Care : the Official Journal of the Critical Care Forum·Wen-Feng FangMeng-Chih Lin
Jul 5, 2011·Drugs & Aging·Ulrich ThiemLudger Pientka
Sep 17, 2011·Internal Medicine·Hajime FukuyamaToru Hashimoto
Sep 29, 2012·Lung India : Official Organ of Indian Chest Society·Dheeraj GuptaUNKNOWN Pneumonia Guidelines Working Group
Jun 12, 2013·European Journal of Internal Medicine·Gurdeep Singh MannuPhyo Kyaw Myint
Mar 5, 2011·Scandinavian Journal of Infectious Diseases·Richard DwyerMats Kalin
Sep 5, 2012·Expert Review of Clinical Pharmacology·Juan F FernandezMarcos I Restrepo
Jan 21, 2016·Expert Review of Respiratory Medicine·Jordi Rello, Antonio Perez
Oct 8, 2015·The American Journal of the Medical Sciences·Adam S VohraGregory W Ruhnke
Feb 13, 2013·Infectious Disease Clinics of North America·Timothy WiemkenJulio Ramirez
Jan 2, 2013·Medicina clínica·Antoni TorresUNKNOWN Grupo de la Guía Multidisciplinar para el Manejo de la Neumonía Adquirida en la Comunidad
Jun 26, 2012·European Journal of Internal Medicine·Jose Manuel PereiraJordi Rello
Apr 7, 2012·Revista Clínica Espanõla·A Julián-JiménezF J Candel González
Aug 27, 2011·Clinics in Chest Medicine·Samuel M Brown, Nathan C Dean
Feb 16, 2010·Medicina clínica·Rafael Zalacain
Nov 2, 2011·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Moises A HuamanScott Kaatz
Sep 18, 2012·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·José LabarèreBeat Mueller
Sep 15, 2012·The Clinical Respiratory Journal·Francesca FoltranAlberto Bruno
Jul 16, 2013·Revista portuguesa de pneumologia·C RibeiroM C Brito
Feb 26, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M R BacciF L A Fonseca
Jun 25, 2015·Revista da Associação Médica Brasileira·Miguel Hernan ViccoHéctor Mario Musacchio
Dec 9, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emma C WallRobert S Heyderman
Oct 12, 2010·Therapeutic Advances in Respiratory Disease·Navdeep K Brar, Michael S Niederman
Jul 4, 2018·Infection & chemotherapy·Mi Suk LeeSungmin Kiem
Mar 4, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Cristina Vazquez Guillamet, Marin H Kollef

❮ Previous
Next ❯

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