Prospective comparison of sevoflurane and desflurane in formerly premature infants undergoing inguinal herniotomy

British Journal of Anaesthesia
S M SaleA R Wolf

Abstract

Formerly premature infants having inguinal herniotomy have been at a high risk of postoperative apnoea, newer less soluble anaesthetic agents may reduce this risk. Thirty infants, under 37 weeks gestation and under 47 weeks post-conceptional age, undergoing inguinal herniotomy had an inhalational induction with sevoflurane and were randomly allocated to sevoflurane (group S) or desflurane (group D) for maintenance. All infants received i.v. atracurium 0.5 mg kg(-1), rectal acetaminophen 20 mg kg(-1) and caudal bupivacaine 0.25% 1 ml kg(-1). Infants were monitored for apnoeas (using nasal thermistry and impedance), haemoglobin oxygen desaturations and bradycardias for 12 h before and after operation with an Alice 4 polysomnograph. Emergence timings were recorded. There was no difference between pre- and postoperative incidence of apnoeas in either group, and no group difference between desflurane and sevoflurane in terms of pre- and postoperative ventilatory events or in the number of apnoeas in the postoperative period (nine patients in group D and five patients in group S had apnoeas). Median times to first movement, tracheal extubation, eye opening and first cry were all faster with group D (group D: 3.0, 10.0, 9.0 and 11.0 m...Continue Reading

References

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Citations

Jul 8, 2010·Nature Reviews. Gastroenterology & Hepatology·Per Brandtzaeg
Oct 7, 2010·Pediatric Research·Malene S CilieborgPer T Sangild
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Jul 6, 2019·Clinical Oral Investigations·Masanori TsukamotoTakeshi Yokoyama

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