Prospective comparison of the sclerosing agents doxycycline and bleomycin for the primary management of malignant pericardial effusion and cardiac tamponade

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
G LiuF A Shepherd

Abstract

To compare the clinical efficacy and toxicity of doxycycline and bleomycin as sclerosing agents in the primary management of malignant pericardial effusion (MPE). Twenty-seven consecutive adult patients referred to a tertiary-care institution for the management of cardiac tamponade and malignancy underwent pericardial drainage through a percutaneously placed pigtail catheter. They were then alternately assigned to undergo bleomycin or doxycycline pericardial sclerosis. There were 13 men and 14 women, with a median age of 59 years. They mainly had lung (70%) and breast cancers (11%), and all had clinical and echocardiographic evidence of cardiac tamponade. Although all patients had successfully placed catheters, six were inadvertently dislodged before sclerosis; 11 underwent bleomycin sclerosis and 10 doxycycline sclerosis. Twenty patients (one early death) were assessable. One patient in each group failed to respond to sclerosis with the initial agent, but both were sclerosed successfully with the other agent. Sclerosis was achieved with a median of two instillations for each agent and total median doses of bleomycin 20 mg and doxycycline 1,250 mg. Seventy percent of doxycycline patients developed significant retrosternal pain,...Continue Reading

Citations

Nov 20, 2009·Journal of Palliative Medicine·Vincent Thai
Jul 23, 2011·Respiration; International Review of Thoracic Diseases·Daniel GompelmannF J F Herth
Oct 13, 2011·Current Treatment Options in Cardiovascular Medicine·Dina M Sparano, R Parker Ward
Apr 5, 2014·Echocardiography·P A N ChandraratnaPeter F Sidarous
Dec 1, 1997·Medizinische Klinik·M BergH Schieffer
Mar 24, 2015·Expert Review of Cardiovascular Therapy·Chiara LestuzziWitold Tomkowski
Aug 17, 2020·Expert Review of Cardiovascular Therapy·Stefano AvondoMassimo Imazio
May 3, 2007·Journal of Palliative Medicine·Vincent Thai, Doreen Oneschuk
Dec 17, 2010·World Journal of Cardiology·Chiara Lestuzzi
Nov 26, 1998·Catheterization and Cardiovascular Diagnosis·E C AzrakR G Bach
Jan 22, 2009·British Journal of Cancer·H KunitohUNKNOWN JCOG Lung Cancer Study Group, Tokyo, Japan
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K ReynenR H Strasser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Riichiroh MaruyamaYukito Ichinose
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
John E PillingPeter Goldstraw
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Kee Won KimKuhn Park
© 2021 Meta ULC. All rights reserved