PMID: 6106736Sep 13, 1980Paper

Prospective controlled trial of injection sclerotherapy in patient with cirrhosis and recent variceal haemorrhage

Lancet
A W ClarkR Williams

Abstract

64 patients with cirrhosis and recent variceal haemorrhage were studied in a prospective randomised trial of injection sclerotherapy by means of a flexible oesophageal sheath. 12 (33%) of the 36 patients in the sclerotherapy group, suffered further bleeds from varices compared with 19 (68%) of the 28 patients receiving standard medical treatment. The risk of bleeding per patient-month of follow up decreased more than threefold with sclerotherapy and the number of patients rebleeding after 2, 6, and 12 months was significantly reduced (p < 0.05). 1-year survival without further bleeding improved significantly with sclerotherapy (46% compared with 6%, p < 0.02), although the difference in overall survival assessed by cumulative life-table analysis was not statistically significant. The main complication of the technique was the development of oesophageal ulcers in some patients.

References

Sep 29, 1979·British Medical Journal·K G Williams, J L Dawson
Nov 11, 1976·The New England Journal of Medicine·J T GalambosA A Salam
Jun 7, 1975·British Medical Journal·M E Bailey, J L Dawson
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams

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Citations

Sep 1, 1986·Digestive Diseases and Sciences·R Williams, D Westaby
Jan 1, 1985·Digestive Diseases and Sciences·L B CohenJ D Waye
Oct 1, 1984·World Journal of Surgery·J M HendersonW D Warren
Mar 1, 1983·Canadian Anaesthetists' Society Journal·L Strunin, J M Davies
Dec 31, 1997·Contraception·R Haimov-KochmanE Y Anteby
Oct 1, 1985·Gastrointestinal Endoscopy·F L CohenS J Taub
May 1, 2001·Alimentary Pharmacology & Therapeutics·A Helmy, P C Hayes
Dec 20, 1984·The New England Journal of Medicine·J P CelloD C Heilbron
Dec 20, 1984·The New England Journal of Medicine·UNKNOWN Copenhagen Esophageal Varices Sclerotherapy Project
Sep 10, 1983·British Medical Journal·P C HayesI A Bouchier
Feb 1, 1985·Gut·S K SarinB S Anand
Aug 1, 1981·British Medical Journal
May 1, 1987·International Journal of Dermatology·S A McClave
Jan 1, 1985·Alcoholism, Clinical and Experimental Research·D Frank, R F Raicht
Jul 1, 1985·American Journal of Surgery·M B DurtschiK H Johansen
Jan 1, 1983·American Journal of Surgery·W D Warren
Nov 1, 1983·The Journal of Pediatrics·F AlvarezD Alagille
Nov 1, 1982·The Annals of Otology, Rhinology, and Laryngology·A M Olsen
Jul 1, 1987·Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation·S K Sarin
Apr 1, 1990·The British Journal of Surgery·S K MathurR Ramakantan
Mar 1, 1990·The British Journal of Surgery·J D GreigD C Carter
Sep 1, 1990·The British Journal of Surgery·A ChaudharyR C Aranya
May 1, 1988·The British Journal of Surgery·E R HowardA P Mowat
Mar 1, 1985·The British Journal of Surgery·R A SpenceG W Johnston
Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S K SarinU K Makwana
Feb 1, 1982·The British Journal of Surgery·J D StamatakisA P Mowat
Feb 1, 1982·The British Journal of Surgery·M S BarsoumA S Ibrahim
Feb 1, 1982·The British Journal of Surgery·M S BarsoumF I Mahmoud
Feb 1, 1984·The British Journal of Surgery·S N Joffe
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D WestabyR Williams
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J KorulaS Yamada
Oct 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Rabeneck

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